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Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures

Background: There are limited effective prophylactic/early treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Viral entry requires spike protein binding to the angiotensin-converting enzyme-2 receptor and cleavage by transmembrane serine protease 2 (TMPRSS2), a ce...

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Detalles Bibliográficos
Autores principales:	Guo, Wenrui, Porter, Linsey M, Crozier, Thomas WM, Coates, Matthew, Jha, Akhilesh, McKie, Mikel, Nathan, James A, Lehner, Paul J, Greenwood, Edward JD, McCaughan, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814636/ https://www.ncbi.nlm.nih.gov/pubmed/35110354 http://dx.doi.org/10.26508/lsa.202101116

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