Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress

The cellular mechanisms required to ensure homeostasis of the hematopoietic niche and the ability of this niche to support hematopoiesis upon stress remain elusive. We here identify Wnt5a in Osterix(+) mesenchymal progenitor and stem cells (MSPCs) as a critical factor for niche-dependent hematopoies...

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Detalles Bibliográficos
Autores principales: Landspersky, Theresa, Saçma, Mehmet, Rivière, Jennifer, Hecker, Judith S., Hettler, Franziska, Hameister, Erik, Brandstetter, Katharina, Istvánffy, Rouzanna, Romero Marquez, Sandra, Ludwig, Romina, Götz, Marilena, Buck, Michèle, Wolf, Martin, Schiemann, Matthias, Ruland, Jürgen, Strunk, Dirk, Shimamura, Akiko, Myers, Kasiani, Yamaguchi, Terry P., Kieslinger, Matthias, Leonhardt, Heinrich, Bassermann, Florian, Götze, Katharina S., Geiger, Hartmut, Schreck, Christina, Oostendorp, Robert A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814682/
https://www.ncbi.nlm.nih.gov/pubmed/34657154
http://dx.doi.org/10.1182/blood.2021011775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814682/
https://www.ncbi.nlm.nih.gov/pubmed/34657154
http://dx.doi.org/10.1182/blood.2021011775

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