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Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence

OBJECTIVE: This study aimed to explore the myelin volume change in patients with mild traumatic brain injury (mTBI) with post-concussion syndrome (PCS) using a multidynamic multiecho (MDME) sequence and automatic whole-brain segmentation. MATERIALS AND METHODS: Forty-one consecutive mTBI patients wi...

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Autores principales: Yoo, Roh-Eul, Choi, Seung Hong, Youn, Sung-Won, Hwang, Moonjung, Kim, Eunkyung, Oh, Byung-Mo, Lee, Ji Ye, Hwang, Inpyeong, Kang, Koung Mi, Yun, Tae Jin, Kim, Ji-hoon, Sohn, Chul-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814703/
https://www.ncbi.nlm.nih.gov/pubmed/35029073
http://dx.doi.org/10.3348/kjr.2021.0253
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author Yoo, Roh-Eul
Choi, Seung Hong
Youn, Sung-Won
Hwang, Moonjung
Kim, Eunkyung
Oh, Byung-Mo
Lee, Ji Ye
Hwang, Inpyeong
Kang, Koung Mi
Yun, Tae Jin
Kim, Ji-hoon
Sohn, Chul-Ho
author_facet Yoo, Roh-Eul
Choi, Seung Hong
Youn, Sung-Won
Hwang, Moonjung
Kim, Eunkyung
Oh, Byung-Mo
Lee, Ji Ye
Hwang, Inpyeong
Kang, Koung Mi
Yun, Tae Jin
Kim, Ji-hoon
Sohn, Chul-Ho
author_sort Yoo, Roh-Eul
collection PubMed
description OBJECTIVE: This study aimed to explore the myelin volume change in patients with mild traumatic brain injury (mTBI) with post-concussion syndrome (PCS) using a multidynamic multiecho (MDME) sequence and automatic whole-brain segmentation. MATERIALS AND METHODS: Forty-one consecutive mTBI patients with PCS and 29 controls, who had undergone MRI including the MDME sequence between October 2016 and April 2018, were included. Myelin volume fraction (MVF) maps were derived from the MDME sequence. After three dimensional T1-based brain segmentation, the average MVF was analyzed at the bilateral cerebral white matter (WM), bilateral cerebral gray matter (GM), corpus callosum, and brainstem. The Mann–Whitney U-test was performed to compare MVF and myelin volume between patients with mTBI and controls. Myelin volume was correlated with neuropsychological test scores using the Spearman rank correlation test. RESULTS: The average MVF at the bilateral cerebral WM was lower in mTBI patients with PCS (median [interquartile range], 25.2% [22.6%–26.4%]) than that in controls (26.8% [25.6%–27.8%]) (p = 0.004). The region-of-interest myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (1.87 cm(3) [1.70–2.05 cm(3)] vs. 2.21 cm(3) [1.86–3.46 cm(3)]; p = 0.003) and brainstem (9.98 cm(3) [9.45–11.00 cm(3)] vs. 11.05 cm(3) [10.10–11.53 cm(3)]; p = 0.015). The total myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (0.45 cm(3) [0.39–0.48 cm(3)] vs. 0.48 cm(3) [0.45–0.54 cm(3)]; p = 0.004) and brainstem (1.45 cm(3) [1.28–1.59 cm(3)] vs. 1.54 cm(3) [1.42–1.67 cm(3)]; p = 0.042). No significant correlation was observed between myelin volume parameters and neuropsychological test scores, except for the total myelin volume at the bilateral cerebral WM and verbal learning test (delayed recall) (r = 0.425; p = 0.048). CONCLUSION: MVF quantified from the MDME sequence was decreased at the bilateral cerebral WM in mTBI patients with PCS. The total myelin volumes at the corpus callosum and brainstem were decreased in mTBI patients with PCS due to atrophic changes.
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spelling pubmed-88147032022-02-10 Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence Yoo, Roh-Eul Choi, Seung Hong Youn, Sung-Won Hwang, Moonjung Kim, Eunkyung Oh, Byung-Mo Lee, Ji Ye Hwang, Inpyeong Kang, Koung Mi Yun, Tae Jin Kim, Ji-hoon Sohn, Chul-Ho Korean J Radiol Neuroimaging and Head & Neck OBJECTIVE: This study aimed to explore the myelin volume change in patients with mild traumatic brain injury (mTBI) with post-concussion syndrome (PCS) using a multidynamic multiecho (MDME) sequence and automatic whole-brain segmentation. MATERIALS AND METHODS: Forty-one consecutive mTBI patients with PCS and 29 controls, who had undergone MRI including the MDME sequence between October 2016 and April 2018, were included. Myelin volume fraction (MVF) maps were derived from the MDME sequence. After three dimensional T1-based brain segmentation, the average MVF was analyzed at the bilateral cerebral white matter (WM), bilateral cerebral gray matter (GM), corpus callosum, and brainstem. The Mann–Whitney U-test was performed to compare MVF and myelin volume between patients with mTBI and controls. Myelin volume was correlated with neuropsychological test scores using the Spearman rank correlation test. RESULTS: The average MVF at the bilateral cerebral WM was lower in mTBI patients with PCS (median [interquartile range], 25.2% [22.6%–26.4%]) than that in controls (26.8% [25.6%–27.8%]) (p = 0.004). The region-of-interest myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (1.87 cm(3) [1.70–2.05 cm(3)] vs. 2.21 cm(3) [1.86–3.46 cm(3)]; p = 0.003) and brainstem (9.98 cm(3) [9.45–11.00 cm(3)] vs. 11.05 cm(3) [10.10–11.53 cm(3)]; p = 0.015). The total myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (0.45 cm(3) [0.39–0.48 cm(3)] vs. 0.48 cm(3) [0.45–0.54 cm(3)]; p = 0.004) and brainstem (1.45 cm(3) [1.28–1.59 cm(3)] vs. 1.54 cm(3) [1.42–1.67 cm(3)]; p = 0.042). No significant correlation was observed between myelin volume parameters and neuropsychological test scores, except for the total myelin volume at the bilateral cerebral WM and verbal learning test (delayed recall) (r = 0.425; p = 0.048). CONCLUSION: MVF quantified from the MDME sequence was decreased at the bilateral cerebral WM in mTBI patients with PCS. The total myelin volumes at the corpus callosum and brainstem were decreased in mTBI patients with PCS due to atrophic changes. The Korean Society of Radiology 2022-02 2022-01-04 /pmc/articles/PMC8814703/ /pubmed/35029073 http://dx.doi.org/10.3348/kjr.2021.0253 Text en Copyright © 2022 The Korean Society of Radiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neuroimaging and Head & Neck
Yoo, Roh-Eul
Choi, Seung Hong
Youn, Sung-Won
Hwang, Moonjung
Kim, Eunkyung
Oh, Byung-Mo
Lee, Ji Ye
Hwang, Inpyeong
Kang, Koung Mi
Yun, Tae Jin
Kim, Ji-hoon
Sohn, Chul-Ho
Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence
title Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence
title_full Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence
title_fullStr Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence
title_full_unstemmed Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence
title_short Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence
title_sort myelin content in mild traumatic brain injury patients with post-concussion syndrome: quantitative assessment with a multidynamic multiecho sequence
topic Neuroimaging and Head & Neck
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814703/
https://www.ncbi.nlm.nih.gov/pubmed/35029073
http://dx.doi.org/10.3348/kjr.2021.0253
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