TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells

Unsatisfied kinetochore-microtubule attachment activates the spindle assembly checkpoint to inhibit the metaphase-anaphase transition. However, some cells eventually override mitotic arrest by mitotic slippage. Here, we show that inactivation of TORC1 kinase elicits mitotic slippage in budding yeast...

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Detalles Bibliográficos
Autores principales: Yamada, Chihiro, Morooka, Aya, Miyazaki, Seira, Nagai, Masayoshi, Mase, Satoru, Iemura, Kenji, Tasnin, Most Naoshia, Takuma, Tsuneyuki, Nakamura, Shotaro, Morshed, Shamsul, Koike, Naoki, Mostofa, Md. Golam, Rahman, Muhammad Arifur, Sharmin, Tasnuva, Katsuta, Haruko, Ohara, Kotaro, Tanaka, Kozo, Ushimaru, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814761/
https://www.ncbi.nlm.nih.gov/pubmed/35141499
http://dx.doi.org/10.1016/j.isci.2021.103675

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