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Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors

BACKGROUND: Cancer immunotherapy shows insufficient efficacy for low immunogenic tumors. Furthermore, tumors often downregulate antigen and major histocompatibility complex expression to escape recognition by T cells, resulting in insufficient T cell receptor (TCR) stimulation in the tumor microenvi...

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Detalles Bibliográficos
Autores principales:	Dotsu, Yosuke, Muraoka, Daisuke, Ogo, Naohisa, Sonoda, Yudai, Yasui, Kiyoshi, Yamaguchi, Hiroyuki, Yagita, Hideo, Mukae, Hiroshi, Asai, Akira, Ikeda, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814813/ https://www.ncbi.nlm.nih.gov/pubmed/35115364 http://dx.doi.org/10.1136/jitc-2021-003958

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