Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement

FMS‐like tyrosine kinase 3‐internal tandem duplication (FLT3‐ITD) mutation‐positive acute myeloid leukemia (AML) has a poor prognosis. We report the first case of successful bridge therapy of novel FLT3 inhibitor, quizartinib, to umbilical cord blood stem cell transplantation for FLT3‐ITD‐positive A...

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Autores principales: Suga, Makiko, Fukushima, Kentaro, Ueda, Tomoaki, Arai, Yasuyuki, Nakagawa, Shunsaku, Minami, Yosuke, Toda, Jun, Hino, Akihisa, Fujita, Jiro, Yokota, Takafumi, Hosen, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815089/
https://www.ncbi.nlm.nih.gov/pubmed/35140970
http://dx.doi.org/10.1002/ccr3.5384
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author Suga, Makiko
Fukushima, Kentaro
Ueda, Tomoaki
Arai, Yasuyuki
Nakagawa, Shunsaku
Minami, Yosuke
Toda, Jun
Hino, Akihisa
Fujita, Jiro
Yokota, Takafumi
Hosen, Naoki
author_facet Suga, Makiko
Fukushima, Kentaro
Ueda, Tomoaki
Arai, Yasuyuki
Nakagawa, Shunsaku
Minami, Yosuke
Toda, Jun
Hino, Akihisa
Fujita, Jiro
Yokota, Takafumi
Hosen, Naoki
author_sort Suga, Makiko
collection PubMed
description FMS‐like tyrosine kinase 3‐internal tandem duplication (FLT3‐ITD) mutation‐positive acute myeloid leukemia (AML) has a poor prognosis. We report the first case of successful bridge therapy of novel FLT3 inhibitor, quizartinib, to umbilical cord blood stem cell transplantation for FLT3‐ITD‐positive AML‐primary induction failure patients with central nervous system involvement.
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spelling pubmed-88150892022-02-08 Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement Suga, Makiko Fukushima, Kentaro Ueda, Tomoaki Arai, Yasuyuki Nakagawa, Shunsaku Minami, Yosuke Toda, Jun Hino, Akihisa Fujita, Jiro Yokota, Takafumi Hosen, Naoki Clin Case Rep Case Reports FMS‐like tyrosine kinase 3‐internal tandem duplication (FLT3‐ITD) mutation‐positive acute myeloid leukemia (AML) has a poor prognosis. We report the first case of successful bridge therapy of novel FLT3 inhibitor, quizartinib, to umbilical cord blood stem cell transplantation for FLT3‐ITD‐positive AML‐primary induction failure patients with central nervous system involvement. John Wiley and Sons Inc. 2022-02-04 /pmc/articles/PMC8815089/ /pubmed/35140970 http://dx.doi.org/10.1002/ccr3.5384 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Suga, Makiko
Fukushima, Kentaro
Ueda, Tomoaki
Arai, Yasuyuki
Nakagawa, Shunsaku
Minami, Yosuke
Toda, Jun
Hino, Akihisa
Fujita, Jiro
Yokota, Takafumi
Hosen, Naoki
Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement
title Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement
title_full Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement
title_fullStr Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement
title_full_unstemmed Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement
title_short Clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for FMS‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement
title_sort clinical implications of combination therapy with quizartinib and craniospinal irradiation for refractory acute myeloid leukemia positive for fms‐like tyrosine kinase 3‐internal tandem duplication with central nervous system involvement
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815089/
https://www.ncbi.nlm.nih.gov/pubmed/35140970
http://dx.doi.org/10.1002/ccr3.5384
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