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Differential regulation of progranulin derived granulin peptides

BACKGROUND: Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed into individual granulin peptides in the lysosome. However, very little is known about the levels and regulations of individ...

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Detalles Bibliográficos
Autores principales:	Zhang, Tingting, Du, Huan, Santos, Mariela Nunez, Wu, Xiaochun, Pagan, Mitchell D., Trigiani, Lianne Jillian, Nishimura, Nozomi, Reinheckel, Thomas, Hu, Fenghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815130/ https://www.ncbi.nlm.nih.gov/pubmed/35120524 http://dx.doi.org/10.1186/s13024-021-00513-9

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