The use of dupilumab in severe atopic dermatitis during pregnancy: a case report

BACKGROUND: Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine. Presently, the only biologic approved for atopic dermatitis is dupilumab with limited data available regarding its safety prof...

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Autores principales: Akhtar, Nabeel H., Khosravi-Hafshejani, Touraj, Akhtar, Daud, Dhadwal, Gurbir, Kanani, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815205/
https://www.ncbi.nlm.nih.gov/pubmed/35115035
http://dx.doi.org/10.1186/s13223-022-00650-w
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author Akhtar, Nabeel H.
Khosravi-Hafshejani, Touraj
Akhtar, Daud
Dhadwal, Gurbir
Kanani, Amin
author_facet Akhtar, Nabeel H.
Khosravi-Hafshejani, Touraj
Akhtar, Daud
Dhadwal, Gurbir
Kanani, Amin
author_sort Akhtar, Nabeel H.
collection PubMed
description BACKGROUND: Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine. Presently, the only biologic approved for atopic dermatitis is dupilumab with limited data available regarding its safety profile in pregnancy. CASE PRESENTATION: We report a case of severe atopic dermatitis treated safely with dupilumab with no adverse maternal or fetal outcomes and resolution of atopic dermatitis postpartum in the absence of maintenance dupilumab therapy. CONCLUSION: Here we demonstrate the safe use of dupilumab in pregnancy. Further research is needed to elucidate the role of dupilumab in the management of atopic dermatitis during pregnancy.
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spelling pubmed-88152052022-02-07 The use of dupilumab in severe atopic dermatitis during pregnancy: a case report Akhtar, Nabeel H. Khosravi-Hafshejani, Touraj Akhtar, Daud Dhadwal, Gurbir Kanani, Amin Allergy Asthma Clin Immunol Case Report BACKGROUND: Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine. Presently, the only biologic approved for atopic dermatitis is dupilumab with limited data available regarding its safety profile in pregnancy. CASE PRESENTATION: We report a case of severe atopic dermatitis treated safely with dupilumab with no adverse maternal or fetal outcomes and resolution of atopic dermatitis postpartum in the absence of maintenance dupilumab therapy. CONCLUSION: Here we demonstrate the safe use of dupilumab in pregnancy. Further research is needed to elucidate the role of dupilumab in the management of atopic dermatitis during pregnancy. BioMed Central 2022-02-03 /pmc/articles/PMC8815205/ /pubmed/35115035 http://dx.doi.org/10.1186/s13223-022-00650-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Akhtar, Nabeel H.
Khosravi-Hafshejani, Touraj
Akhtar, Daud
Dhadwal, Gurbir
Kanani, Amin
The use of dupilumab in severe atopic dermatitis during pregnancy: a case report
title The use of dupilumab in severe atopic dermatitis during pregnancy: a case report
title_full The use of dupilumab in severe atopic dermatitis during pregnancy: a case report
title_fullStr The use of dupilumab in severe atopic dermatitis during pregnancy: a case report
title_full_unstemmed The use of dupilumab in severe atopic dermatitis during pregnancy: a case report
title_short The use of dupilumab in severe atopic dermatitis during pregnancy: a case report
title_sort use of dupilumab in severe atopic dermatitis during pregnancy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815205/
https://www.ncbi.nlm.nih.gov/pubmed/35115035
http://dx.doi.org/10.1186/s13223-022-00650-w
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