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Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature
Data on the vertical transmission rate of COVID-19 in pregnancy are limited, although data reporting mother-fetal transmission in the second trimester of pregnancy are controversial. We described a case of second-trimester twin stillbirth in a woman with SARS-CoV-2 infection in which placental and f...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815276/ https://www.ncbi.nlm.nih.gov/pubmed/35131495 http://dx.doi.org/10.1016/j.ajogmf.2022.100589 |
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author | Patanè, Luisa Cadamuro, Massimiliano Massazza, Gabriella Pirola, Serena Stagnati, Valentina Comerio, Chiara Carnelli, Marco Arosio, Marco Callegaro, Anna Paola` Tebaldi, Paola Rigoli, Elena Gianatti, Andrea Morotti, Denise |
author_facet | Patanè, Luisa Cadamuro, Massimiliano Massazza, Gabriella Pirola, Serena Stagnati, Valentina Comerio, Chiara Carnelli, Marco Arosio, Marco Callegaro, Anna Paola` Tebaldi, Paola Rigoli, Elena Gianatti, Andrea Morotti, Denise |
author_sort | Patanè, Luisa |
collection | PubMed |
description | Data on the vertical transmission rate of COVID-19 in pregnancy are limited, although data reporting mother-fetal transmission in the second trimester of pregnancy are controversial. We described a case of second-trimester twin stillbirth in a woman with SARS-CoV-2 infection in which placental and fetal markers of infection were detected, despite the absence of respiratory syndrome. The patient developed clinical chorioamnionitis and spontaneously delivered 2 stillborn infants. Placental histology and immunohistochemistry demonstrated SARS-CoV-2 infection mostly within the syncytiotrophoblast, and fetal autopsy showed the development of interstitial pneumonia. Our findings demonstrated that in utero vertical transmission is possible in asymptomatic pregnant women with SARS-CoV-2 infection and that infection can lead to severe morbidity in the second trimester of pregnancy. |
format | Online Article Text |
id | pubmed-8815276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88152762022-02-04 Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature Patanè, Luisa Cadamuro, Massimiliano Massazza, Gabriella Pirola, Serena Stagnati, Valentina Comerio, Chiara Carnelli, Marco Arosio, Marco Callegaro, Anna Paola` Tebaldi, Paola Rigoli, Elena Gianatti, Andrea Morotti, Denise Am J Obstet Gynecol MFM Clinical Perspective Data on the vertical transmission rate of COVID-19 in pregnancy are limited, although data reporting mother-fetal transmission in the second trimester of pregnancy are controversial. We described a case of second-trimester twin stillbirth in a woman with SARS-CoV-2 infection in which placental and fetal markers of infection were detected, despite the absence of respiratory syndrome. The patient developed clinical chorioamnionitis and spontaneously delivered 2 stillborn infants. Placental histology and immunohistochemistry demonstrated SARS-CoV-2 infection mostly within the syncytiotrophoblast, and fetal autopsy showed the development of interstitial pneumonia. Our findings demonstrated that in utero vertical transmission is possible in asymptomatic pregnant women with SARS-CoV-2 infection and that infection can lead to severe morbidity in the second trimester of pregnancy. Elsevier Inc. 2022-05 2022-02-04 /pmc/articles/PMC8815276/ /pubmed/35131495 http://dx.doi.org/10.1016/j.ajogmf.2022.100589 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Clinical Perspective Patanè, Luisa Cadamuro, Massimiliano Massazza, Gabriella Pirola, Serena Stagnati, Valentina Comerio, Chiara Carnelli, Marco Arosio, Marco Callegaro, Anna Paola` Tebaldi, Paola Rigoli, Elena Gianatti, Andrea Morotti, Denise Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature |
title | Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature |
title_full | Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature |
title_fullStr | Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature |
title_full_unstemmed | Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature |
title_short | Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature |
title_sort | evidence of vertical transmission of sars-cov-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. case report and review of the literature |
topic | Clinical Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815276/ https://www.ncbi.nlm.nih.gov/pubmed/35131495 http://dx.doi.org/10.1016/j.ajogmf.2022.100589 |
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