Non-inferiority trials

Studies sometimes aim to show that a new intervention is not substantially worse than the existing standard of care while offering some benefits, for example, lower cost, decreased toxicity, or easier administration. Such studies are called non-inferiority (NI) trials. In this article, we look at so...

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Autores principales: Ranganathan, Priya, Pramesh, C. S., Aggarwal, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Statistics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815668/
https://www.ncbi.nlm.nih.gov/pubmed/35198430
http://dx.doi.org/10.4103/picr.picr_245_21
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author Ranganathan, Priya
Pramesh, C. S.
Aggarwal, Rakesh
author_facet Ranganathan, Priya
Pramesh, C. S.
Aggarwal, Rakesh
author_sort Ranganathan, Priya
collection PubMed
description Studies sometimes aim to show that a new intervention is not substantially worse than the existing standard of care while offering some benefits, for example, lower cost, decreased toxicity, or easier administration. Such studies are called non-inferiority (NI) trials. In this article, we look at some aspects of NI trials.
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spelling pubmed-88156682022-02-22 Non-inferiority trials Ranganathan, Priya Pramesh, C. S. Aggarwal, Rakesh Perspect Clin Res Statistics Studies sometimes aim to show that a new intervention is not substantially worse than the existing standard of care while offering some benefits, for example, lower cost, decreased toxicity, or easier administration. Such studies are called non-inferiority (NI) trials. In this article, we look at some aspects of NI trials. Wolters Kluwer - Medknow 2022 2022-01-06 /pmc/articles/PMC8815668/ /pubmed/35198430 http://dx.doi.org/10.4103/picr.picr_245_21 Text en Copyright: © 2022 Perspectives in Clinical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Statistics
Ranganathan, Priya
Pramesh, C. S.
Aggarwal, Rakesh
Non-inferiority trials
title Non-inferiority trials
title_full Non-inferiority trials
title_fullStr Non-inferiority trials
title_full_unstemmed Non-inferiority trials
title_short Non-inferiority trials
title_sort non-inferiority trials
topic Statistics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815668/
https://www.ncbi.nlm.nih.gov/pubmed/35198430
http://dx.doi.org/10.4103/picr.picr_245_21
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