Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C

Background: We describe the first pediatric case of a 10-month-old boy with MIS-C who developed fulminant acute liver failure with associated giant cell transformation and a fatal outcome, after ruling out other infectious, metabolic, genetic, and autoimmune causes of liver failure following the usu...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonilla Gonzalez, Carolina, Hincapié Echeverría, Marcela, Plazas Pachón, Rocio, Mora Umaña, Paola, Diaz Gómez, Berlly Lucia, Gualdron Barreto, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815702/
https://www.ncbi.nlm.nih.gov/pubmed/35127589
http://dx.doi.org/10.3389/fped.2021.780258
_version_ 1784645295521398784
author Bonilla Gonzalez, Carolina
Hincapié Echeverría, Marcela
Plazas Pachón, Rocio
Mora Umaña, Paola
Diaz Gómez, Berlly Lucia
Gualdron Barreto, Nathalie
author_facet Bonilla Gonzalez, Carolina
Hincapié Echeverría, Marcela
Plazas Pachón, Rocio
Mora Umaña, Paola
Diaz Gómez, Berlly Lucia
Gualdron Barreto, Nathalie
author_sort Bonilla Gonzalez, Carolina
collection PubMed
description Background: We describe the first pediatric case of a 10-month-old boy with MIS-C who developed fulminant acute liver failure with associated giant cell transformation and a fatal outcome, after ruling out other infectious, metabolic, genetic, and autoimmune causes of liver failure following the usual algorithms for approaching the etiology. Although the patient received the main treatment strategies for liver failure, he had a fatal outcome. A clinical autopsy was considered as part of the diagnostic approach, which showed evidence of giant cell transformation.
format Online
Article
Text
id pubmed-8815702
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88157022022-02-05 Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C Bonilla Gonzalez, Carolina Hincapié Echeverría, Marcela Plazas Pachón, Rocio Mora Umaña, Paola Diaz Gómez, Berlly Lucia Gualdron Barreto, Nathalie Front Pediatr Pediatrics Background: We describe the first pediatric case of a 10-month-old boy with MIS-C who developed fulminant acute liver failure with associated giant cell transformation and a fatal outcome, after ruling out other infectious, metabolic, genetic, and autoimmune causes of liver failure following the usual algorithms for approaching the etiology. Although the patient received the main treatment strategies for liver failure, he had a fatal outcome. A clinical autopsy was considered as part of the diagnostic approach, which showed evidence of giant cell transformation. Frontiers Media S.A. 2022-01-21 /pmc/articles/PMC8815702/ /pubmed/35127589 http://dx.doi.org/10.3389/fped.2021.780258 Text en Copyright © 2022 Bonilla Gonzalez, Hincapié Echeverría, Plazas Pachón, Mora Umaña, Diaz Gómez and Gualdron Barreto. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Bonilla Gonzalez, Carolina
Hincapié Echeverría, Marcela
Plazas Pachón, Rocio
Mora Umaña, Paola
Diaz Gómez, Berlly Lucia
Gualdron Barreto, Nathalie
Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C
title Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C
title_full Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C
title_fullStr Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C
title_full_unstemmed Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C
title_short Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C
title_sort case report: fatal acute liver failure with giant cell transformation in a pediatric patient associated with mis-c
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815702/
https://www.ncbi.nlm.nih.gov/pubmed/35127589
http://dx.doi.org/10.3389/fped.2021.780258
work_keys_str_mv AT bonillagonzalezcarolina casereportfatalacuteliverfailurewithgiantcelltransformationinapediatricpatientassociatedwithmisc
AT hincapieecheverriamarcela casereportfatalacuteliverfailurewithgiantcelltransformationinapediatricpatientassociatedwithmisc
AT plazaspachonrocio casereportfatalacuteliverfailurewithgiantcelltransformationinapediatricpatientassociatedwithmisc
AT moraumanapaola casereportfatalacuteliverfailurewithgiantcelltransformationinapediatricpatientassociatedwithmisc
AT diazgomezberllylucia casereportfatalacuteliverfailurewithgiantcelltransformationinapediatricpatientassociatedwithmisc
AT gualdronbarretonathalie casereportfatalacuteliverfailurewithgiantcelltransformationinapediatricpatientassociatedwithmisc

Ejemplares similares