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An Unusual Presentation of Diffuse Large B-Cell Lymphoma

Hyperlactemia is a rare and potentially fatal complication of hematologic malignancies, as well as an oncological emergency, which requires a fast diagnosis and early therapeutic management, as these interventions may alter disease prognosis. Herein, we present a case of secondary liver-biopsy-confi...

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Autores principales: Gkoufa, Aikaterini, Georgakopoulou, Vasiliki E, Lakiotaki, Eleftheria, Cholongitas, Evangelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815724/
https://www.ncbi.nlm.nih.gov/pubmed/35154918
http://dx.doi.org/10.7759/cureus.20927
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author Gkoufa, Aikaterini
Georgakopoulou, Vasiliki E
Lakiotaki, Eleftheria
Cholongitas, Evangelos
author_facet Gkoufa, Aikaterini
Georgakopoulou, Vasiliki E
Lakiotaki, Eleftheria
Cholongitas, Evangelos
author_sort Gkoufa, Aikaterini
collection PubMed
description Hyperlactemia is a rare and potentially fatal complication of hematologic malignancies, as well as an oncological emergency, which requires a fast diagnosis and early therapeutic management, as these interventions may alter disease prognosis. Herein, we present a case of secondary liver-biopsy-confirmed diffuse large B-cell lymphoma (DLBCL), presented with elevated liver enzymes and lactic acidosis, without depicted hepatic lesions, hepatosplenomegaly, or enlarged lymph nodes on computed tomography. This case confirms the poor prognosis of cases with delayed diagnostic intervention and highlights the importance of early clinical suspicion, liver biopsy, and prompt treatment initiation.
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spelling pubmed-88157242022-02-10 An Unusual Presentation of Diffuse Large B-Cell Lymphoma Gkoufa, Aikaterini Georgakopoulou, Vasiliki E Lakiotaki, Eleftheria Cholongitas, Evangelos Cureus Internal Medicine Hyperlactemia is a rare and potentially fatal complication of hematologic malignancies, as well as an oncological emergency, which requires a fast diagnosis and early therapeutic management, as these interventions may alter disease prognosis. Herein, we present a case of secondary liver-biopsy-confirmed diffuse large B-cell lymphoma (DLBCL), presented with elevated liver enzymes and lactic acidosis, without depicted hepatic lesions, hepatosplenomegaly, or enlarged lymph nodes on computed tomography. This case confirms the poor prognosis of cases with delayed diagnostic intervention and highlights the importance of early clinical suspicion, liver biopsy, and prompt treatment initiation. Cureus 2022-01-04 /pmc/articles/PMC8815724/ /pubmed/35154918 http://dx.doi.org/10.7759/cureus.20927 Text en Copyright © 2022, Gkoufa et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Gkoufa, Aikaterini
Georgakopoulou, Vasiliki E
Lakiotaki, Eleftheria
Cholongitas, Evangelos
An Unusual Presentation of Diffuse Large B-Cell Lymphoma
title An Unusual Presentation of Diffuse Large B-Cell Lymphoma
title_full An Unusual Presentation of Diffuse Large B-Cell Lymphoma
title_fullStr An Unusual Presentation of Diffuse Large B-Cell Lymphoma
title_full_unstemmed An Unusual Presentation of Diffuse Large B-Cell Lymphoma
title_short An Unusual Presentation of Diffuse Large B-Cell Lymphoma
title_sort unusual presentation of diffuse large b-cell lymphoma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815724/
https://www.ncbi.nlm.nih.gov/pubmed/35154918
http://dx.doi.org/10.7759/cureus.20927
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