Mosaic dysfunction of mitophagy in mitochondrial muscle disease

Mitophagy is a quality control mechanism that eliminates damaged mitochondria, yet its significance in mammalian pathophysiology and aging has remained unclear. Here, we report that mitophagy contributes to mitochondrial dysfunction in skeletal muscle of aged mice and human patients. The early disea...

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Detalles Bibliográficos
Autores principales: Mito, Takayuki, Vincent, Amy E., Faitg, Julie, Taylor, Robert W., Khan, Nahid A., McWilliams, Thomas G., Suomalainen, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815775/
https://www.ncbi.nlm.nih.gov/pubmed/35030325
http://dx.doi.org/10.1016/j.cmet.2021.12.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815775/
https://www.ncbi.nlm.nih.gov/pubmed/35030325
http://dx.doi.org/10.1016/j.cmet.2021.12.017

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