Oxidant resistant human apolipoprotein A-I functions similarly to the unmodified human isoform in delaying atherosclerosis progression and promoting atherosclerosis regression in hyperlipidemic mice

BACKGROUND: Transgenic overexpression of apolipoprotein A-I (apoA1) has been shown to delay atherosclerosis lesion progression and promote lesion regression in mouse models; however, apoA1 is subject to oxidation by myeloperoxidase (MPO) and loss of function. The activity of oxidant resistant human...

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Detalles Bibliográficos
Autores principales: Opoku, Emmanuel, Berisha, Stela, Brubaker, Gregory, Robinet, Peggy, Smith, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815868/
https://www.ncbi.nlm.nih.gov/pubmed/35120132
http://dx.doi.org/10.1371/journal.pone.0259751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815868/
https://www.ncbi.nlm.nih.gov/pubmed/35120132
http://dx.doi.org/10.1371/journal.pone.0259751

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