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Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity

Pancreatic cancer remains largely unresponsive to immune modulatory therapy attributable in part to an immunosuppressive, desmoplastic tumor microenvironment. Here, we analyze mechanisms of cancer cell-autonomous resistance to T cells. We used a 3D co-culture model of cancer cell spheroids from the...

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Detalles Bibliográficos
Autores principales:	Lin, Yuan-Na, Schmidt, Marcel O., Sharif, Ghada M., Vietsch, Eveline E., Kiliti, Amber J., Barefoot, Megan E., Riegel, Anna T., Wellstein, Anton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816404/ https://www.ncbi.nlm.nih.gov/pubmed/35127250 http://dx.doi.org/10.1080/2162402X.2022.2027136

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