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Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort
BACKGROUND: Diabetic nephropathy (DN) can affect quality of life (QoL) because it requires arduous lifelong management. This study analyzed QoL differences between DN patients and patients with other chronic kidney diseases (CKDs). METHODS: The analysis included subjects (n = 1,766) from the KNOW-CK...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Nephrology
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816412/ https://www.ncbi.nlm.nih.gov/pubmed/34781641 http://dx.doi.org/10.23876/j.krcp.21.068 |
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author | Kim, Hyunsuk Lee, Joongyub Choi, Gwang Ho Jeong, Hae Min Kim, Seok hyung Gu, Jae Eon Yoo, Jeong-Ju Han, Miyeun Kim, Hyo-Jin Sung, Su-Ah Han, Seung Hyeok Kim, Yeong Hoon Yoon, Jong-Woo Heo, Jongho Oh, Kook-Hwan |
author_facet | Kim, Hyunsuk Lee, Joongyub Choi, Gwang Ho Jeong, Hae Min Kim, Seok hyung Gu, Jae Eon Yoo, Jeong-Ju Han, Miyeun Kim, Hyo-Jin Sung, Su-Ah Han, Seung Hyeok Kim, Yeong Hoon Yoon, Jong-Woo Heo, Jongho Oh, Kook-Hwan |
author_sort | Kim, Hyunsuk |
collection | PubMed |
description | BACKGROUND: Diabetic nephropathy (DN) can affect quality of life (QoL) because it requires arduous lifelong management. This study analyzed QoL differences between DN patients and patients with other chronic kidney diseases (CKDs). METHODS: The analysis included subjects (n = 1,766) from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort who completed the Kidney Disease Quality of Life Short Form questionnaire. After implementing propensity score matching (PSM) using factors that affect the QoL of DN patients, QoL differences between DN and non-DN participants were examined. RESULTS: Among all DN patients (n = 390), higher QoL scores were found for taller subjects, and lower scores were found for those who were unemployed or unmarried, received Medical Aid, had lower economic status, had higher platelet counts or alkaline phosphatase levels, or used clopidogrel or insulin. After PSM, the 239 matched DN subjects reported significantly lower patient satisfaction (59.9 vs. 64.5, p = 0.02) and general health (35.3 vs. 39.1, p = 0.04) than the 239 non-DN subjects. Scores decreased in both groups during the 5-year follow-up, and the scores in the work status, sexual function, and role-physical domains were lower among DN patients than non-DN patients, though those differences were not statistically significant. CONCLUSION: Socioeconomic factors of DN were strong risk factors for impaired QoL, as were high platelet, alkaline phosphatase, and clopidogrel and insulin use. Clinicians should keep in mind that the QoL of DN patients might decrease in some domains compared with non-DN CKDs. |
format | Online Article Text |
id | pubmed-8816412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-88164122022-02-14 Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort Kim, Hyunsuk Lee, Joongyub Choi, Gwang Ho Jeong, Hae Min Kim, Seok hyung Gu, Jae Eon Yoo, Jeong-Ju Han, Miyeun Kim, Hyo-Jin Sung, Su-Ah Han, Seung Hyeok Kim, Yeong Hoon Yoon, Jong-Woo Heo, Jongho Oh, Kook-Hwan Kidney Res Clin Pract Original Article BACKGROUND: Diabetic nephropathy (DN) can affect quality of life (QoL) because it requires arduous lifelong management. This study analyzed QoL differences between DN patients and patients with other chronic kidney diseases (CKDs). METHODS: The analysis included subjects (n = 1,766) from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort who completed the Kidney Disease Quality of Life Short Form questionnaire. After implementing propensity score matching (PSM) using factors that affect the QoL of DN patients, QoL differences between DN and non-DN participants were examined. RESULTS: Among all DN patients (n = 390), higher QoL scores were found for taller subjects, and lower scores were found for those who were unemployed or unmarried, received Medical Aid, had lower economic status, had higher platelet counts or alkaline phosphatase levels, or used clopidogrel or insulin. After PSM, the 239 matched DN subjects reported significantly lower patient satisfaction (59.9 vs. 64.5, p = 0.02) and general health (35.3 vs. 39.1, p = 0.04) than the 239 non-DN subjects. Scores decreased in both groups during the 5-year follow-up, and the scores in the work status, sexual function, and role-physical domains were lower among DN patients than non-DN patients, though those differences were not statistically significant. CONCLUSION: Socioeconomic factors of DN were strong risk factors for impaired QoL, as were high platelet, alkaline phosphatase, and clopidogrel and insulin use. Clinicians should keep in mind that the QoL of DN patients might decrease in some domains compared with non-DN CKDs. The Korean Society of Nephrology 2022-01 2021-11-08 /pmc/articles/PMC8816412/ /pubmed/34781641 http://dx.doi.org/10.23876/j.krcp.21.068 Text en Copyright © 2022 The Korean Society of Nephrology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial and No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) which permits unrestricted non-commercial use, distribution of the material without any modifications, and reproduction in any medium, provided the original works properly cited. |
spellingShingle | Original Article Kim, Hyunsuk Lee, Joongyub Choi, Gwang Ho Jeong, Hae Min Kim, Seok hyung Gu, Jae Eon Yoo, Jeong-Ju Han, Miyeun Kim, Hyo-Jin Sung, Su-Ah Han, Seung Hyeok Kim, Yeong Hoon Yoon, Jong-Woo Heo, Jongho Oh, Kook-Hwan Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort |
title | Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort |
title_full | Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort |
title_fullStr | Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort |
title_full_unstemmed | Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort |
title_short | Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort |
title_sort | quality of life in patients with diabetic nephropathy: findings from the know-ckd (korean cohort study for outcomes in patients with chronic kidney disease) cohort |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816412/ https://www.ncbi.nlm.nih.gov/pubmed/34781641 http://dx.doi.org/10.23876/j.krcp.21.068 |
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