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Robotic automation of droplet microfluidics

Droplet microfluidics enables powerful analytic capabilities but often requires workflows involving macro- and microfluidic processing steps that are cumbersome to perform manually. Here, we demonstrate the automation of droplet microfluidics with commercial fluid-handling robotics. The workflows in...

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Detalles Bibliográficos
Autores principales: Tran, Tuan M., Kim, Samuel C., Modavi, Cyrus, Abate, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816516/
https://www.ncbi.nlm.nih.gov/pubmed/35145570
http://dx.doi.org/10.1063/5.0064265
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author Tran, Tuan M.
Kim, Samuel C.
Modavi, Cyrus
Abate, Adam R.
author_facet Tran, Tuan M.
Kim, Samuel C.
Modavi, Cyrus
Abate, Adam R.
author_sort Tran, Tuan M.
collection PubMed
description Droplet microfluidics enables powerful analytic capabilities but often requires workflows involving macro- and microfluidic processing steps that are cumbersome to perform manually. Here, we demonstrate the automation of droplet microfluidics with commercial fluid-handling robotics. The workflows incorporate common microfluidic devices including droplet generators, mergers, and sorters and utilize the robot's native capabilities for thermal control, incubation, and plate scanning. The ability to automate microfluidic devices using commercial fluid handling will speed up the integration of these methods into biological workflows.
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spelling pubmed-88165162022-02-09 Robotic automation of droplet microfluidics Tran, Tuan M. Kim, Samuel C. Modavi, Cyrus Abate, Adam R. Biomicrofluidics Regular Articles Droplet microfluidics enables powerful analytic capabilities but often requires workflows involving macro- and microfluidic processing steps that are cumbersome to perform manually. Here, we demonstrate the automation of droplet microfluidics with commercial fluid-handling robotics. The workflows incorporate common microfluidic devices including droplet generators, mergers, and sorters and utilize the robot's native capabilities for thermal control, incubation, and plate scanning. The ability to automate microfluidic devices using commercial fluid handling will speed up the integration of these methods into biological workflows. AIP Publishing LLC 2022-02-03 /pmc/articles/PMC8816516/ /pubmed/35145570 http://dx.doi.org/10.1063/5.0064265 Text en © 2022 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Regular Articles
Tran, Tuan M.
Kim, Samuel C.
Modavi, Cyrus
Abate, Adam R.
Robotic automation of droplet microfluidics
title Robotic automation of droplet microfluidics
title_full Robotic automation of droplet microfluidics
title_fullStr Robotic automation of droplet microfluidics
title_full_unstemmed Robotic automation of droplet microfluidics
title_short Robotic automation of droplet microfluidics
title_sort robotic automation of droplet microfluidics
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816516/
https://www.ncbi.nlm.nih.gov/pubmed/35145570
http://dx.doi.org/10.1063/5.0064265
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