Cargando…
A review on 3D printing functional brain model
Modern neuroscience increasingly relies on 3D models to study neural circuitry, nerve regeneration, and neural disease. Several different biofabrication approaches have been explored to create 3D neural tissue model structures. Among them, 3D bioprinting has shown to have great potential to emerge a...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816519/ https://www.ncbi.nlm.nih.gov/pubmed/35145569 http://dx.doi.org/10.1063/5.0074631 |
_version_ | 1784645453884686336 |
---|---|
author | Samanipour, Roya Tahmooressi, Hamed Rezaei Nejad, Hojatollah Hirano, Minoru Shin, Su-Royn Hoorfar, Mina |
author_facet | Samanipour, Roya Tahmooressi, Hamed Rezaei Nejad, Hojatollah Hirano, Minoru Shin, Su-Royn Hoorfar, Mina |
author_sort | Samanipour, Roya |
collection | PubMed |
description | Modern neuroscience increasingly relies on 3D models to study neural circuitry, nerve regeneration, and neural disease. Several different biofabrication approaches have been explored to create 3D neural tissue model structures. Among them, 3D bioprinting has shown to have great potential to emerge as a high-throughput/high precision biofabrication strategy that can address the growing need for 3D neural models. Here, we have reviewed the design principles for neural tissue engineering. The main challenge to adapt printing technologies for biofabrication of neural tissue models is the development of neural bioink, i.e., a biomaterial with printability and gelation properties and also suitable for neural tissue culture. This review shines light on a vast range of biomaterials as well as the fundamentals of 3D neural tissue printing. Also, advances in 3D bioprinting technologies are reviewed especially for bioprinted neural models. Finally, the techniques used to evaluate the fabricated 2D and 3D neural models are discussed and compared in terms of feasibility and functionality. |
format | Online Article Text |
id | pubmed-8816519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-88165192022-02-09 A review on 3D printing functional brain model Samanipour, Roya Tahmooressi, Hamed Rezaei Nejad, Hojatollah Hirano, Minoru Shin, Su-Royn Hoorfar, Mina Biomicrofluidics Review Articles Modern neuroscience increasingly relies on 3D models to study neural circuitry, nerve regeneration, and neural disease. Several different biofabrication approaches have been explored to create 3D neural tissue model structures. Among them, 3D bioprinting has shown to have great potential to emerge as a high-throughput/high precision biofabrication strategy that can address the growing need for 3D neural models. Here, we have reviewed the design principles for neural tissue engineering. The main challenge to adapt printing technologies for biofabrication of neural tissue models is the development of neural bioink, i.e., a biomaterial with printability and gelation properties and also suitable for neural tissue culture. This review shines light on a vast range of biomaterials as well as the fundamentals of 3D neural tissue printing. Also, advances in 3D bioprinting technologies are reviewed especially for bioprinted neural models. Finally, the techniques used to evaluate the fabricated 2D and 3D neural models are discussed and compared in terms of feasibility and functionality. AIP Publishing LLC 2022-02-03 /pmc/articles/PMC8816519/ /pubmed/35145569 http://dx.doi.org/10.1063/5.0074631 Text en © 2022 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Articles Samanipour, Roya Tahmooressi, Hamed Rezaei Nejad, Hojatollah Hirano, Minoru Shin, Su-Royn Hoorfar, Mina A review on 3D printing functional brain model |
title | A review on 3D printing functional brain model |
title_full | A review on 3D printing functional brain model |
title_fullStr | A review on 3D printing functional brain model |
title_full_unstemmed | A review on 3D printing functional brain model |
title_short | A review on 3D printing functional brain model |
title_sort | review on 3d printing functional brain model |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816519/ https://www.ncbi.nlm.nih.gov/pubmed/35145569 http://dx.doi.org/10.1063/5.0074631 |
work_keys_str_mv | AT samanipourroya areviewon3dprintingfunctionalbrainmodel AT tahmooressihamed areviewon3dprintingfunctionalbrainmodel AT rezaeinejadhojatollah areviewon3dprintingfunctionalbrainmodel AT hiranominoru areviewon3dprintingfunctionalbrainmodel AT shinsuroyn areviewon3dprintingfunctionalbrainmodel AT hoorfarmina areviewon3dprintingfunctionalbrainmodel AT samanipourroya reviewon3dprintingfunctionalbrainmodel AT tahmooressihamed reviewon3dprintingfunctionalbrainmodel AT rezaeinejadhojatollah reviewon3dprintingfunctionalbrainmodel AT hiranominoru reviewon3dprintingfunctionalbrainmodel AT shinsuroyn reviewon3dprintingfunctionalbrainmodel AT hoorfarmina reviewon3dprintingfunctionalbrainmodel |