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Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells

Various kinds of controlled microtopographies can promote osteogenic differentiation of mesenchymal stem cells (MSCs), such as microgrooves, micropillars, and micropits. However, the optimal shape, size, and mechanism remain unclear. In this review, we summarize the relationship between the paramete...

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Detalles Bibliográficos
Autores principales: Chen, Chengxin, Zhu, Yuanjing, Wang, Ran, Han, Yu, Zhou, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816539/
https://www.ncbi.nlm.nih.gov/pubmed/35126944
http://dx.doi.org/10.1155/2022/7179723
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author Chen, Chengxin
Zhu, Yuanjing
Wang, Ran
Han, Yu
Zhou, Hongbo
author_facet Chen, Chengxin
Zhu, Yuanjing
Wang, Ran
Han, Yu
Zhou, Hongbo
author_sort Chen, Chengxin
collection PubMed
description Various kinds of controlled microtopographies can promote osteogenic differentiation of mesenchymal stem cells (MSCs), such as microgrooves, micropillars, and micropits. However, the optimal shape, size, and mechanism remain unclear. In this review, we summarize the relationship between the parameters of different microtopographies and the behavior of MSCs. Then, we try to reveal the potential mechanism between them. The results showed that the microgrooves with a width of 4–60 μm and ridge width <10 μm, micropillars with parameters less than 10 μm, and square micropits had the full potential to promote osteogenic differentiation of MSCs, while the micromorphology of the same size could induce larger focal adhesions (FAs), well-organized cytoskeleton, and superior cell areas. Therefore, such events are possibly mediated by microtopography-induced mechanotransduction pathways.
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spelling pubmed-88165392022-02-05 Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells Chen, Chengxin Zhu, Yuanjing Wang, Ran Han, Yu Zhou, Hongbo J Healthc Eng Review Article Various kinds of controlled microtopographies can promote osteogenic differentiation of mesenchymal stem cells (MSCs), such as microgrooves, micropillars, and micropits. However, the optimal shape, size, and mechanism remain unclear. In this review, we summarize the relationship between the parameters of different microtopographies and the behavior of MSCs. Then, we try to reveal the potential mechanism between them. The results showed that the microgrooves with a width of 4–60 μm and ridge width <10 μm, micropillars with parameters less than 10 μm, and square micropits had the full potential to promote osteogenic differentiation of MSCs, while the micromorphology of the same size could induce larger focal adhesions (FAs), well-organized cytoskeleton, and superior cell areas. Therefore, such events are possibly mediated by microtopography-induced mechanotransduction pathways. Hindawi 2022-01-28 /pmc/articles/PMC8816539/ /pubmed/35126944 http://dx.doi.org/10.1155/2022/7179723 Text en Copyright © 2022 Chengxin Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Chengxin
Zhu, Yuanjing
Wang, Ran
Han, Yu
Zhou, Hongbo
Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells
title Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells
title_full Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells
title_fullStr Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells
title_full_unstemmed Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells
title_short Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells
title_sort effect of controlled microtopography on osteogenic differentiation of mesenchymal stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816539/
https://www.ncbi.nlm.nih.gov/pubmed/35126944
http://dx.doi.org/10.1155/2022/7179723
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