Cargando…

Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

BACKGROUND: Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. Therefore, we performed a systematic re...

Descripción completa

Detalles Bibliográficos
Autores principales: Kandelouei, Tahmineh, Abbasifard, Mitra, Imani, Danyal, Aslani, Saeed, Razi, Bahman, Fasihi, Mahdieh, Shafiekhani, Sajad, Mohammadi, Keyhan, Jamialahmadi, Tannaz, Reiner, Željko, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816584/
https://www.ncbi.nlm.nih.gov/pubmed/35125965
http://dx.doi.org/10.1155/2022/8732360
_version_ 1784645468569993216
author Kandelouei, Tahmineh
Abbasifard, Mitra
Imani, Danyal
Aslani, Saeed
Razi, Bahman
Fasihi, Mahdieh
Shafiekhani, Sajad
Mohammadi, Keyhan
Jamialahmadi, Tannaz
Reiner, Željko
Sahebkar, Amirhossein
author_facet Kandelouei, Tahmineh
Abbasifard, Mitra
Imani, Danyal
Aslani, Saeed
Razi, Bahman
Fasihi, Mahdieh
Shafiekhani, Sajad
Mohammadi, Keyhan
Jamialahmadi, Tannaz
Reiner, Željko
Sahebkar, Amirhossein
author_sort Kandelouei, Tahmineh
collection PubMed
description BACKGROUND: Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. Therefore, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effect of statins on CRP and hs-CRP levels in patients with cardiovascular diseases (CVDs). METHODS: Literature search of the major databases was performed to find eligible RCTs assessing the effect of statins on serum levels of CRP and hs-CRP from the inception until the last week of April 2021. The effect sizes were determined for weighted mean difference (WMD) and 95% confidence intervals (CI). RESULTS: 26 studies were identified (3010 patients and 2968 controls) for hs-CRP and 20 studies (3026 patients and 2968 controls) for CRP. Statins reduced the serum levels of hs-CRP (WMD = −0.97 mg/L; 95% CI: -1.26 to -0.68 mg/L; P < 0.001) and CRP (WMD = −3.05 mg/L; 95% CI: -4.86 to -1.25 mg/L; P < 0.001) in patients with CVDs. Statins decreased the serum levels of hs-CRP in patients receiving both high-intensity and moderate/low-intensity treatments with these drugs. In addition, the duration of treatment longer than 10 weeks decreased hs-CRP levels. Only high-intensity statin treatment could marginally decrease serum levels of CRP in CVDs patients. CONCLUSIONS: This meta-analysis showed the efficacy of statins to reduce the concentrations of CRP and hs-CRP in patients with different types of CVDs.
format Online
Article
Text
id pubmed-8816584
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-88165842022-02-05 Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Kandelouei, Tahmineh Abbasifard, Mitra Imani, Danyal Aslani, Saeed Razi, Bahman Fasihi, Mahdieh Shafiekhani, Sajad Mohammadi, Keyhan Jamialahmadi, Tannaz Reiner, Željko Sahebkar, Amirhossein Mediators Inflamm Review Article BACKGROUND: Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. Therefore, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effect of statins on CRP and hs-CRP levels in patients with cardiovascular diseases (CVDs). METHODS: Literature search of the major databases was performed to find eligible RCTs assessing the effect of statins on serum levels of CRP and hs-CRP from the inception until the last week of April 2021. The effect sizes were determined for weighted mean difference (WMD) and 95% confidence intervals (CI). RESULTS: 26 studies were identified (3010 patients and 2968 controls) for hs-CRP and 20 studies (3026 patients and 2968 controls) for CRP. Statins reduced the serum levels of hs-CRP (WMD = −0.97 mg/L; 95% CI: -1.26 to -0.68 mg/L; P < 0.001) and CRP (WMD = −3.05 mg/L; 95% CI: -4.86 to -1.25 mg/L; P < 0.001) in patients with CVDs. Statins decreased the serum levels of hs-CRP in patients receiving both high-intensity and moderate/low-intensity treatments with these drugs. In addition, the duration of treatment longer than 10 weeks decreased hs-CRP levels. Only high-intensity statin treatment could marginally decrease serum levels of CRP in CVDs patients. CONCLUSIONS: This meta-analysis showed the efficacy of statins to reduce the concentrations of CRP and hs-CRP in patients with different types of CVDs. Hindawi 2022-01-28 /pmc/articles/PMC8816584/ /pubmed/35125965 http://dx.doi.org/10.1155/2022/8732360 Text en Copyright © 2022 Tahmineh Kandelouei et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kandelouei, Tahmineh
Abbasifard, Mitra
Imani, Danyal
Aslani, Saeed
Razi, Bahman
Fasihi, Mahdieh
Shafiekhani, Sajad
Mohammadi, Keyhan
Jamialahmadi, Tannaz
Reiner, Željko
Sahebkar, Amirhossein
Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_fullStr Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_short Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_sort effect of statins on serum level of hs-crp and crp in patients with cardiovascular diseases: a systematic review and meta-analysis of randomized controlled trials
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816584/
https://www.ncbi.nlm.nih.gov/pubmed/35125965
http://dx.doi.org/10.1155/2022/8732360
work_keys_str_mv AT kandeloueitahmineh effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT abbasifardmitra effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT imanidanyal effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT aslanisaeed effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT razibahman effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT fasihimahdieh effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT shafiekhanisajad effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT mohammadikeyhan effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT jamialahmaditannaz effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT reinerzeljko effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT sahebkaramirhossein effectofstatinsonserumlevelofhscrpandcrpinpatientswithcardiovasculardiseasesasystematicreviewandmetaanalysisofrandomizedcontrolledtrials