Phosphorylation at Ser 727 Increases STAT3 Interaction with PKCε Regulating Neuron–Glia Crosstalk via IL-6-Mediated Hyperalgesia In Vivo and In Vitro

METHODS: A rat hyperalgesia model was induced using an intraplantar injection of Freund's complete adjuvant (FCA) or an intrathecal injection of IL-6. Mechanical allodynia was evaluated using von Frey filament tests after intrathecal injections of T-5224 (c-Fos/AP-1 inhibitor), minocycline (Min...

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Detalles Bibliográficos
Autores principales: Li, Xiongjuan, Zhou, Biqiang, Yang, Han, Yang, Xinping, Zhao, Zhao, Pan, Zhenglong, Liao, Xinran, Jian, Wenling, Liu, Yuqiang, Lu, Han, Xue, Qingsheng, Luo, Yan, Yu, Buwei, Huang, Huansen, Ma, Daqing, Liu, Zhiheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816592/
https://www.ncbi.nlm.nih.gov/pubmed/35125963
http://dx.doi.org/10.1155/2022/2782080

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