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Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells

Cathepsin D (Cat D) is well known for its roles in metastasis, angiogenesis, proliferation, and carcinogenesis in cancer. Despite Cat D being a promising target in cancer cells, effects and underlying mechanism of its inhibition remain unclear. Here, we investigated the plausibility of using Cat D i...

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Detalles Bibliográficos
Autores principales:	Seo, Seung Un, Woo, Seon Min, Im, Seung-Soon, Jang, Younghoon, Han, Eugene, Kim, Sang Hyun, Lee, Hongchan, Lee, Hyun-Shik, Nam, Ju-Ock, Gabrielson, Edward, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816936/ https://www.ncbi.nlm.nih.gov/pubmed/35121737 http://dx.doi.org/10.1038/s41419-022-04581-7

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