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LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance

Aged bone marrow mesenchymal stem cells (BMSCs) exhibit aberrant self-renewal and lineage specification, which contribute to imbalanced bone-fat and progressive bone loss. In addition to known master regulators of lineage commitment, it is crucial to identify pivotal switches governing the specific...

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Detalles Bibliográficos
Autores principales: Zhang, Hengguo, Xu, Rongyao, Li, Bang, Xin, Zhili, Ling, Ziji, Zhu, Weiwen, Li, Xiang, Zhang, Ping, Fu, Yu, Chen, Jiyu, Liu, Laikui, Cheng, Jie, Jiang, Hongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816946/
https://www.ncbi.nlm.nih.gov/pubmed/34497381
http://dx.doi.org/10.1038/s41418-021-00858-0