Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer

HIV Envelope (Env) is the main vaccine target for induction of neutralizing antibodies. Stabilizing Env into native-like trimer (NLT) conformations is required for recombinant protein immunogens to induce autologous neutralizing antibodies(nAbs) against difficult to neutralize HIV strains (tier-2) i...

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Detalles Bibliográficos
Autores principales: Xu, Ziyang, Walker, Susanne, Wise, Megan C., Chokkalingam, Neethu, Purwar, Mansi, Moore, Alan, Tello-Ruiz, Edgar, Wu, Yuanhan, Majumdar, Sonali, Konrath, Kylie M., Kulkarni, Abhijeet, Tursi, Nicholas J., Zaidi, Faraz I., Reuschel, Emma L., Patel, Ishaan, Obeirne, April, Du, Jianqiu, Schultheis, Katherine, Gites, Lauren, Smith, Trevor, Mendoza, Janess, Broderick, Kate E., Humeau, Laurent, Pallesen, Jesper, Weiner, David B., Kulp, Daniel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816947/
https://www.ncbi.nlm.nih.gov/pubmed/35121758
http://dx.doi.org/10.1038/s41467-022-28363-z

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