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Bioenzyme-based nanomedicines for enhanced cancer therapy

Bioenzymes that catalyze reactions within living systems show a great promise for cancer therapy, particularly when they are integrated with nanoparticles to improve their accumulation into tumor sites. Nanomedicines can deliver toxic bioenzymes into cancer cells to directly cause their death for ca...

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Detalles Bibliográficos
Autores principales: Ding, Mengbin, Zhang, Yijing, Li, Jingchao, Pu, Kanyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816986/
https://www.ncbi.nlm.nih.gov/pubmed/35119544
http://dx.doi.org/10.1186/s40580-022-00297-8
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author Ding, Mengbin
Zhang, Yijing
Li, Jingchao
Pu, Kanyi
author_facet Ding, Mengbin
Zhang, Yijing
Li, Jingchao
Pu, Kanyi
author_sort Ding, Mengbin
collection PubMed
description Bioenzymes that catalyze reactions within living systems show a great promise for cancer therapy, particularly when they are integrated with nanoparticles to improve their accumulation into tumor sites. Nanomedicines can deliver toxic bioenzymes into cancer cells to directly cause their death for cancer treatment. By modulating the tumor microenvironment, such as pH, glucose concentration, hypoxia, redox levels and heat shock protein expression, bioenzyme-based nanomedicines play crucial roles in improving the therapeutic efficacy of treatments. Moreover, bioenzyme-mediated degradation of the major components in tumor extracellular matrix greatly increases the penetration and retention of nanoparticles in deep tumors and infiltration of immune cells into tumor tissues, thus enhancing the efficacies of chemotherapy, phototherapy and immunotherapy. In this review, we summarize the recent progresses of bioenzyme-based nanomedicines for enhanced cancer therapy. The design and working mechanisms of the bioenzyme-based nanomedicines to achieve enhanced chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, radiotherapy and immunotherapy are introduced in detail. At the end of this review, a conclusion and current challenges and perspectives in this field are given.
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spelling pubmed-88169862022-02-16 Bioenzyme-based nanomedicines for enhanced cancer therapy Ding, Mengbin Zhang, Yijing Li, Jingchao Pu, Kanyi Nano Converg Review Bioenzymes that catalyze reactions within living systems show a great promise for cancer therapy, particularly when they are integrated with nanoparticles to improve their accumulation into tumor sites. Nanomedicines can deliver toxic bioenzymes into cancer cells to directly cause their death for cancer treatment. By modulating the tumor microenvironment, such as pH, glucose concentration, hypoxia, redox levels and heat shock protein expression, bioenzyme-based nanomedicines play crucial roles in improving the therapeutic efficacy of treatments. Moreover, bioenzyme-mediated degradation of the major components in tumor extracellular matrix greatly increases the penetration and retention of nanoparticles in deep tumors and infiltration of immune cells into tumor tissues, thus enhancing the efficacies of chemotherapy, phototherapy and immunotherapy. In this review, we summarize the recent progresses of bioenzyme-based nanomedicines for enhanced cancer therapy. The design and working mechanisms of the bioenzyme-based nanomedicines to achieve enhanced chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, radiotherapy and immunotherapy are introduced in detail. At the end of this review, a conclusion and current challenges and perspectives in this field are given. Springer Singapore 2022-02-04 /pmc/articles/PMC8816986/ /pubmed/35119544 http://dx.doi.org/10.1186/s40580-022-00297-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ding, Mengbin
Zhang, Yijing
Li, Jingchao
Pu, Kanyi
Bioenzyme-based nanomedicines for enhanced cancer therapy
title Bioenzyme-based nanomedicines for enhanced cancer therapy
title_full Bioenzyme-based nanomedicines for enhanced cancer therapy
title_fullStr Bioenzyme-based nanomedicines for enhanced cancer therapy
title_full_unstemmed Bioenzyme-based nanomedicines for enhanced cancer therapy
title_short Bioenzyme-based nanomedicines for enhanced cancer therapy
title_sort bioenzyme-based nanomedicines for enhanced cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816986/
https://www.ncbi.nlm.nih.gov/pubmed/35119544
http://dx.doi.org/10.1186/s40580-022-00297-8
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