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Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus

The role of stress and its neuroendocrine mediators in tinnitus is unclear. In this study, we measure cortisol as an indicator of hypothalamus–pituitary–adrenal (HPA) axis alterations and brain-derived neurotrophic factor (BDNF) as a marker of adaptive neuroplasticity in hair of chronic tinnitus pat...

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Autores principales: Basso, Laura, Boecking, Benjamin, Neff, Patrick, Brueggemann, Petra, Peters, Eva M. J., Mazurek, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817043/
https://www.ncbi.nlm.nih.gov/pubmed/35121746
http://dx.doi.org/10.1038/s41598-022-04811-0
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author Basso, Laura
Boecking, Benjamin
Neff, Patrick
Brueggemann, Petra
Peters, Eva M. J.
Mazurek, Birgit
author_facet Basso, Laura
Boecking, Benjamin
Neff, Patrick
Brueggemann, Petra
Peters, Eva M. J.
Mazurek, Birgit
author_sort Basso, Laura
collection PubMed
description The role of stress and its neuroendocrine mediators in tinnitus is unclear. In this study, we measure cortisol as an indicator of hypothalamus–pituitary–adrenal (HPA) axis alterations and brain-derived neurotrophic factor (BDNF) as a marker of adaptive neuroplasticity in hair of chronic tinnitus patients to investigate relationships with tinnitus-related and psychological factors. Cross-sectional data from chronic tinnitus inpatients were analyzed. Data collection included hair sampling, pure tone audiometry, tinnitus pitch and loudness matching, and psychometric questionnaires. Elastic net regressions with n-fold cross-validation were performed for cortisol (N = 91) and BDNF (N = 87). For hair-cortisol (R(2) = 0.10), the strongest effects were sampling in autumn and body-mass index (BMI) (positive), followed by tinnitus loudness (positive) and smoking (negative). For hair-BDNF (R(2) = 0.28), the strongest effects were hearing aid use, shift work (positive), and tinnitus loudness (negative), followed by smoking, tinnitus-related distress (Tinnitus Questionnaire), number of experienced traumatic events (negative), and physical health-related quality of life (Short Form-12 Health Survey) (positive). These findings suggest that in chronic tinnitus patients, higher perceived tinnitus loudness is associated with higher hair-cortisol and lower hair-BDNF, and higher tinnitus-related distress with lower hair-BDNF. Regarding hair-BDNF, traumatic experiences appear to have additional stress-related effects, whereas hearing aid use and high physical health-related quality of life appear beneficial. Implications include the potential use of hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness or distress and the need for intensive future research into chronic stress-related HPA axis and neuroplasticity alterations in chronic tinnitus.
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spelling pubmed-88170432022-02-09 Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus Basso, Laura Boecking, Benjamin Neff, Patrick Brueggemann, Petra Peters, Eva M. J. Mazurek, Birgit Sci Rep Article The role of stress and its neuroendocrine mediators in tinnitus is unclear. In this study, we measure cortisol as an indicator of hypothalamus–pituitary–adrenal (HPA) axis alterations and brain-derived neurotrophic factor (BDNF) as a marker of adaptive neuroplasticity in hair of chronic tinnitus patients to investigate relationships with tinnitus-related and psychological factors. Cross-sectional data from chronic tinnitus inpatients were analyzed. Data collection included hair sampling, pure tone audiometry, tinnitus pitch and loudness matching, and psychometric questionnaires. Elastic net regressions with n-fold cross-validation were performed for cortisol (N = 91) and BDNF (N = 87). For hair-cortisol (R(2) = 0.10), the strongest effects were sampling in autumn and body-mass index (BMI) (positive), followed by tinnitus loudness (positive) and smoking (negative). For hair-BDNF (R(2) = 0.28), the strongest effects were hearing aid use, shift work (positive), and tinnitus loudness (negative), followed by smoking, tinnitus-related distress (Tinnitus Questionnaire), number of experienced traumatic events (negative), and physical health-related quality of life (Short Form-12 Health Survey) (positive). These findings suggest that in chronic tinnitus patients, higher perceived tinnitus loudness is associated with higher hair-cortisol and lower hair-BDNF, and higher tinnitus-related distress with lower hair-BDNF. Regarding hair-BDNF, traumatic experiences appear to have additional stress-related effects, whereas hearing aid use and high physical health-related quality of life appear beneficial. Implications include the potential use of hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness or distress and the need for intensive future research into chronic stress-related HPA axis and neuroplasticity alterations in chronic tinnitus. Nature Publishing Group UK 2022-02-04 /pmc/articles/PMC8817043/ /pubmed/35121746 http://dx.doi.org/10.1038/s41598-022-04811-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Basso, Laura
Boecking, Benjamin
Neff, Patrick
Brueggemann, Petra
Peters, Eva M. J.
Mazurek, Birgit
Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus
title Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus
title_full Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus
title_fullStr Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus
title_full_unstemmed Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus
title_short Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus
title_sort hair-cortisol and hair-bdnf as biomarkers of tinnitus loudness and distress in chronic tinnitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817043/
https://www.ncbi.nlm.nih.gov/pubmed/35121746
http://dx.doi.org/10.1038/s41598-022-04811-0
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