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Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis
Endothelial cells are heterogeneous, stemming from multiple organs, but there is still little known about the connection between the brain and kidney endothelial cells, especially in homeostasis. In this study, scRNA-seq results were obtained to compare genetic profiles and biological features of ti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817106/ https://www.ncbi.nlm.nih.gov/pubmed/35132377 http://dx.doi.org/10.1155/2022/5239255 |
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author | Huang, Xiaohua Huang, Zhongshi Wei, Zhongheng Feng, Yun Li, Xuebin Xu, Anding Jian, Chongdong |
author_facet | Huang, Xiaohua Huang, Zhongshi Wei, Zhongheng Feng, Yun Li, Xuebin Xu, Anding Jian, Chongdong |
author_sort | Huang, Xiaohua |
collection | PubMed |
description | Endothelial cells are heterogeneous, stemming from multiple organs, but there is still little known about the connection between the brain and kidney endothelial cells, especially in homeostasis. In this study, scRNA-seq results were obtained to compare genetic profiles and biological features of tissue-specific endothelial cells. On this basis, seven endothelial cell subpopulations were identified, two of which were upregulated genes in pathways related to stroke and/or depression, as characterized by neuroinflammation. This study revealed the similarities and distinctions between brain and kidney endothelial cells, providing baseline information needed to fully understand the relationship between renal diseases and neuroinflammation, such as stroke and depression. |
format | Online Article Text |
id | pubmed-8817106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88171062022-02-06 Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis Huang, Xiaohua Huang, Zhongshi Wei, Zhongheng Feng, Yun Li, Xuebin Xu, Anding Jian, Chongdong Biomed Res Int Research Article Endothelial cells are heterogeneous, stemming from multiple organs, but there is still little known about the connection between the brain and kidney endothelial cells, especially in homeostasis. In this study, scRNA-seq results were obtained to compare genetic profiles and biological features of tissue-specific endothelial cells. On this basis, seven endothelial cell subpopulations were identified, two of which were upregulated genes in pathways related to stroke and/or depression, as characterized by neuroinflammation. This study revealed the similarities and distinctions between brain and kidney endothelial cells, providing baseline information needed to fully understand the relationship between renal diseases and neuroinflammation, such as stroke and depression. Hindawi 2022-01-28 /pmc/articles/PMC8817106/ /pubmed/35132377 http://dx.doi.org/10.1155/2022/5239255 Text en Copyright © 2022 Xiaohua Huang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Huang, Xiaohua Huang, Zhongshi Wei, Zhongheng Feng, Yun Li, Xuebin Xu, Anding Jian, Chongdong Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis |
title | Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis |
title_full | Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis |
title_fullStr | Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis |
title_full_unstemmed | Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis |
title_short | Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis |
title_sort | transcriptome comparison of brain and kidney endothelial cells in homeostasis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817106/ https://www.ncbi.nlm.nih.gov/pubmed/35132377 http://dx.doi.org/10.1155/2022/5239255 |
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