Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites

The present paper is a commentary to ‘Identification and characterization of hADSC‐derived exosome proteins from different isolation methods’ (Huang et al. 2021; 10.1111/jcmm.16775). Given the enthusiasm for the potential of mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs), some con...

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Detalles Bibliográficos
Autores principales: Courageux, Yvan, Monguió‐Tortajada, Marta, Prat‐Vidal, Cristina, Bayes‐Genis, Antoni, Roura, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817141/
https://www.ncbi.nlm.nih.gov/pubmed/34931446
http://dx.doi.org/10.1111/jcmm.17112
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author Courageux, Yvan
Monguió‐Tortajada, Marta
Prat‐Vidal, Cristina
Bayes‐Genis, Antoni
Roura, Santiago
author_facet Courageux, Yvan
Monguió‐Tortajada, Marta
Prat‐Vidal, Cristina
Bayes‐Genis, Antoni
Roura, Santiago
author_sort Courageux, Yvan
collection PubMed
description The present paper is a commentary to ‘Identification and characterization of hADSC‐derived exosome proteins from different isolation methods’ (Huang et al. 2021; 10.1111/jcmm.16775). Given the enthusiasm for the potential of mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs), some considerations deserve attention as they move through successive stages of research and application into humans. We herein remark the prerequisite of generating that evidence ensuring a high consistency in safety, composition and biological activity of the intended MSC‐EV preparations, and the suitability of disparate isolation techniques to produce efficacious EV preparations and fulfil requirements for standardized clinical‐grade biomanufacturing.
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spelling pubmed-88171412022-02-08 Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites Courageux, Yvan Monguió‐Tortajada, Marta Prat‐Vidal, Cristina Bayes‐Genis, Antoni Roura, Santiago J Cell Mol Med Commentary The present paper is a commentary to ‘Identification and characterization of hADSC‐derived exosome proteins from different isolation methods’ (Huang et al. 2021; 10.1111/jcmm.16775). Given the enthusiasm for the potential of mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs), some considerations deserve attention as they move through successive stages of research and application into humans. We herein remark the prerequisite of generating that evidence ensuring a high consistency in safety, composition and biological activity of the intended MSC‐EV preparations, and the suitability of disparate isolation techniques to produce efficacious EV preparations and fulfil requirements for standardized clinical‐grade biomanufacturing. John Wiley and Sons Inc. 2021-12-20 2022-02 /pmc/articles/PMC8817141/ /pubmed/34931446 http://dx.doi.org/10.1111/jcmm.17112 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Courageux, Yvan
Monguió‐Tortajada, Marta
Prat‐Vidal, Cristina
Bayes‐Genis, Antoni
Roura, Santiago
Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
title Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
title_full Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
title_fullStr Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
title_full_unstemmed Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
title_short Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
title_sort clinical translation of mesenchymal stromal cell extracellular vesicles: considerations on scientific rationale and production requisites
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817141/
https://www.ncbi.nlm.nih.gov/pubmed/34931446
http://dx.doi.org/10.1111/jcmm.17112
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