Cargando…

Evolutionary history of type II transmembrane serine proteases involved in viral priming

Type II transmembrane serine proteases (TTSPs) are a family of trypsin-like membrane-anchored serine proteases that play key roles in the regulation of some crucial processes in physiological conditions, including cardiac function, digestion, cellular iron homeostasis, epidermal differentiation, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Forni, Diego, Sironi, Manuela, Cagliani, Rachele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817155/
https://www.ncbi.nlm.nih.gov/pubmed/35122525
http://dx.doi.org/10.1007/s00439-022-02435-y
_version_ 1784645578752262144
author Forni, Diego
Sironi, Manuela
Cagliani, Rachele
author_facet Forni, Diego
Sironi, Manuela
Cagliani, Rachele
author_sort Forni, Diego
collection PubMed
description Type II transmembrane serine proteases (TTSPs) are a family of trypsin-like membrane-anchored serine proteases that play key roles in the regulation of some crucial processes in physiological conditions, including cardiac function, digestion, cellular iron homeostasis, epidermal differentiation, and immune responses. However, some of them, in particular TTSPs expressed in the human airways, were identified as host factors that promote the proteolytic activation and spread of respiratory viruses such as influenza virus, human metapneumovirus, and coronaviruses, including SARS-CoV-2. Given their involvement in viral priming, we hypothesized that members of the TTSP family may represent targets of positive selection, possibly as the result of virus-driven pressure. Thus, we investigated the evolutionary history of sixteen TTSP genes in mammals. Evolutionary analyses indicate that most of the TTSP genes that have a verified role in viral proteolytic activation present signals of pervasive positive selection, suggesting that viral infections represent a selective pressure driving the evolution of these proteases. We also evaluated genetic diversity in human populations and we identified targets of balancing selection in TMPRSS2 and TMPRSS4. This scenario may be the result of an ancestral and still ongoing host–pathogen arms race. Overall, our results provide evolutionary information about candidate functional sites and polymorphic positions in TTSP genes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00439-022-02435-y.
format Online
Article
Text
id pubmed-8817155
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-88171552022-02-07 Evolutionary history of type II transmembrane serine proteases involved in viral priming Forni, Diego Sironi, Manuela Cagliani, Rachele Hum Genet Original Investigation Type II transmembrane serine proteases (TTSPs) are a family of trypsin-like membrane-anchored serine proteases that play key roles in the regulation of some crucial processes in physiological conditions, including cardiac function, digestion, cellular iron homeostasis, epidermal differentiation, and immune responses. However, some of them, in particular TTSPs expressed in the human airways, were identified as host factors that promote the proteolytic activation and spread of respiratory viruses such as influenza virus, human metapneumovirus, and coronaviruses, including SARS-CoV-2. Given their involvement in viral priming, we hypothesized that members of the TTSP family may represent targets of positive selection, possibly as the result of virus-driven pressure. Thus, we investigated the evolutionary history of sixteen TTSP genes in mammals. Evolutionary analyses indicate that most of the TTSP genes that have a verified role in viral proteolytic activation present signals of pervasive positive selection, suggesting that viral infections represent a selective pressure driving the evolution of these proteases. We also evaluated genetic diversity in human populations and we identified targets of balancing selection in TMPRSS2 and TMPRSS4. This scenario may be the result of an ancestral and still ongoing host–pathogen arms race. Overall, our results provide evolutionary information about candidate functional sites and polymorphic positions in TTSP genes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00439-022-02435-y. Springer Berlin Heidelberg 2022-02-05 2022 /pmc/articles/PMC8817155/ /pubmed/35122525 http://dx.doi.org/10.1007/s00439-022-02435-y Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Investigation
Forni, Diego
Sironi, Manuela
Cagliani, Rachele
Evolutionary history of type II transmembrane serine proteases involved in viral priming
title Evolutionary history of type II transmembrane serine proteases involved in viral priming
title_full Evolutionary history of type II transmembrane serine proteases involved in viral priming
title_fullStr Evolutionary history of type II transmembrane serine proteases involved in viral priming
title_full_unstemmed Evolutionary history of type II transmembrane serine proteases involved in viral priming
title_short Evolutionary history of type II transmembrane serine proteases involved in viral priming
title_sort evolutionary history of type ii transmembrane serine proteases involved in viral priming
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817155/
https://www.ncbi.nlm.nih.gov/pubmed/35122525
http://dx.doi.org/10.1007/s00439-022-02435-y
work_keys_str_mv AT fornidiego evolutionaryhistoryoftypeiitransmembraneserineproteasesinvolvedinviralpriming
AT sironimanuela evolutionaryhistoryoftypeiitransmembraneserineproteasesinvolvedinviralpriming
AT caglianirachele evolutionaryhistoryoftypeiitransmembraneserineproteasesinvolvedinviralpriming