A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis

CD3-bispecific antibodies are a new class of immunotherapeutic drugs against cancer. The pharmacological activity of CD3-bispecifics is typically assessed through in vitro assays of cancer cell lines co-cultured with human peripheral blood mononuclear cells (PBMCs). Assay results depend on experimen...

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Detalles Bibliográficos
Autores principales: Van De Vyver, Arthur, Eigenmann, Miro, Ovacik, Meric, Pohl, Christian, Herter, Sylvia, Weinzierl, Tina, Fauti, Tanja, Klein, Christian, Lehr, Thorsten, Bacac, Marina, Walz, Antje-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817205/
https://www.ncbi.nlm.nih.gov/pubmed/34862519
http://dx.doi.org/10.1208/s12248-021-00637-2

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