Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer’s disease pathology

Conversion of β-amyloid (Aβ) peptides from soluble random-coil to aggregated protein enriched with β-sheet-rich intermediates has been suggested to play a role in the degeneration of neurons and development of Alzheimer’s disease (AD) pathology. Aggregation of Aβ peptide can be prompted by a variety...

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Detalles Bibliográficos
Autores principales: Paul, Pallabi Sil, Cho, Jae-Young, Wu, Qi, Karthivashan, Govindarajan, Grabovac, Emily, Wille, Holger, Kulka, Mariana, Kar, Satyabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817552/
https://www.ncbi.nlm.nih.gov/pubmed/35120558
http://dx.doi.org/10.1186/s12951-022-01269-0

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