Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu

BACKGROUND: Human induced pluripotent stem cell (hiPSC)-derived brain endothelial-like cells (iBECs) are a robust, scalable, and translatable model of the human blood–brain barrier (BBB). Prior works have shown that high transendothelial electrical resistance (TEER) persists in iBECs for at least 2 ...

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Detalles Bibliográficos
Autores principales: Williams, Lindsey M., Fujimoto, Takashi, Weaver, Riley R., Logsdon, Aric F., Evitts, Kira M., Young, Jessica E., Banks, William A., Erickson, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817611/
https://www.ncbi.nlm.nih.gov/pubmed/35123529
http://dx.doi.org/10.1186/s12987-022-00307-1

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