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CGRP: A New Endogenous Cell Stemness Maintenance Molecule

Stem cells have the ability of self-replication and multidirectional differentiation, but the mechanism of how stem cells “maintain” this ability and how to “decide” to give up this state and differentiate into cells with specific functions is still unknown. The Nobel Prize in physiology and medicin...

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Detalles Bibliográficos
Autores principales: Lv, Xiaoting, Chen, Qingquan, Zhang, Shuyu, Gao, Feng, Liu, Qicai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817839/
https://www.ncbi.nlm.nih.gov/pubmed/35132349
http://dx.doi.org/10.1155/2022/4107433
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author Lv, Xiaoting
Chen, Qingquan
Zhang, Shuyu
Gao, Feng
Liu, Qicai
author_facet Lv, Xiaoting
Chen, Qingquan
Zhang, Shuyu
Gao, Feng
Liu, Qicai
author_sort Lv, Xiaoting
collection PubMed
description Stem cells have the ability of self-replication and multidirectional differentiation, but the mechanism of how stem cells “maintain” this ability and how to “decide” to give up this state and differentiate into cells with specific functions is still unknown. The Nobel Prize in physiology and medicine in 2021 was awarded to “temperature and tactile receptor,” which made the pain receptor TRPV1-calcitonin gene-related peptide (CGRP) pathway active again. The activation and blocking technology of CGRP has been applied to many clinical diseases. CGRP gene has complex structure and transcription process, with multiple methylation and other modification sites. It has been considered as a research hotspot and difficulty since its discovery. Drug manipulation of TRPV1 and inhibition of CGRP might improve metabolism and prolong longevity. However, whether the TRPV1-neuropeptide-CGRP pathway is directly or indirectly involved in stem cell self-replication and multidirectional differentiation is unclear. Recent studies have found that CGRP is closely related to the migration and differentiation of tumor stem cells, which may be realized by turning off or turning on the CGRP gene expression in stem cells and activating a variety of ways to regulate stem cell niches. In this study, we reviewed the advances in researches concentrated on the biological effects of CGRP as a new endogenous switching of cell stemness.
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spelling pubmed-88178392022-02-06 CGRP: A New Endogenous Cell Stemness Maintenance Molecule Lv, Xiaoting Chen, Qingquan Zhang, Shuyu Gao, Feng Liu, Qicai Oxid Med Cell Longev Review Article Stem cells have the ability of self-replication and multidirectional differentiation, but the mechanism of how stem cells “maintain” this ability and how to “decide” to give up this state and differentiate into cells with specific functions is still unknown. The Nobel Prize in physiology and medicine in 2021 was awarded to “temperature and tactile receptor,” which made the pain receptor TRPV1-calcitonin gene-related peptide (CGRP) pathway active again. The activation and blocking technology of CGRP has been applied to many clinical diseases. CGRP gene has complex structure and transcription process, with multiple methylation and other modification sites. It has been considered as a research hotspot and difficulty since its discovery. Drug manipulation of TRPV1 and inhibition of CGRP might improve metabolism and prolong longevity. However, whether the TRPV1-neuropeptide-CGRP pathway is directly or indirectly involved in stem cell self-replication and multidirectional differentiation is unclear. Recent studies have found that CGRP is closely related to the migration and differentiation of tumor stem cells, which may be realized by turning off or turning on the CGRP gene expression in stem cells and activating a variety of ways to regulate stem cell niches. In this study, we reviewed the advances in researches concentrated on the biological effects of CGRP as a new endogenous switching of cell stemness. Hindawi 2022-01-29 /pmc/articles/PMC8817839/ /pubmed/35132349 http://dx.doi.org/10.1155/2022/4107433 Text en Copyright © 2022 Xiaoting Lv et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lv, Xiaoting
Chen, Qingquan
Zhang, Shuyu
Gao, Feng
Liu, Qicai
CGRP: A New Endogenous Cell Stemness Maintenance Molecule
title CGRP: A New Endogenous Cell Stemness Maintenance Molecule
title_full CGRP: A New Endogenous Cell Stemness Maintenance Molecule
title_fullStr CGRP: A New Endogenous Cell Stemness Maintenance Molecule
title_full_unstemmed CGRP: A New Endogenous Cell Stemness Maintenance Molecule
title_short CGRP: A New Endogenous Cell Stemness Maintenance Molecule
title_sort cgrp: a new endogenous cell stemness maintenance molecule
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817839/
https://www.ncbi.nlm.nih.gov/pubmed/35132349
http://dx.doi.org/10.1155/2022/4107433
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