Deciphering how naturally occurring sequence features impact the phase behaviors of disordered prion-like domains

Prion-like low complexity domains (PLCDs) have distinctive sequence grammars that determine their driving forces for phase separation. Here, we uncover the physicochemical underpinnings of how evolutionarily conserved compositional biases influence the phase behavior of PLCDs. We interpret our resul...

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Detalles Bibliográficos
Autores principales: Bremer, Anne, Farag, Mina, Borcherds, Wade M., Peran, Ivan, Martin, Erik W., Pappu, Rohit V., Mittag, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818026/
https://www.ncbi.nlm.nih.gov/pubmed/34931046
http://dx.doi.org/10.1038/s41557-021-00840-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818026/
https://www.ncbi.nlm.nih.gov/pubmed/34931046
http://dx.doi.org/10.1038/s41557-021-00840-w

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