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The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity
INTRODUCTION: Oxidative stress plays a critical role in the pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior has not been clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ila...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818118/ https://www.ncbi.nlm.nih.gov/pubmed/35173920 http://dx.doi.org/10.32598/bcn.2021.1917.1 |
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author | Oshnokhah, Mahin Bagheri, Maryam Ghaneialvar, Hori Haghani, Karimeh Khorshidi, Ali Shahbazi, Ali Salari, Sajjad |
author_facet | Oshnokhah, Mahin Bagheri, Maryam Ghaneialvar, Hori Haghani, Karimeh Khorshidi, Ali Shahbazi, Ali Salari, Sajjad |
author_sort | Oshnokhah, Mahin |
collection | PubMed |
description | INTRODUCTION: Oxidative stress plays a critical role in the pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior has not been clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city. METHODS: Fifty suicide attempters and 40 control subjects (volunteers) aged 18–35 years were studied in the current experiment. To consider the oxidant-antioxidant status, serum levels of Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide Dismutase (SOD), and the Total Antioxidant Capacity (TAC) were measured. RESULTS: Serum levels of SOD and TAC were significantly lower in the suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters compared to the control groups. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the control groups. CONCLUSION: The oxidative stress without MDA elevation, detected in suicide attempters, can be considered a biochemical hallmark in suicide behavior. |
format | Online Article Text |
id | pubmed-8818118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-88181182022-02-15 The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity Oshnokhah, Mahin Bagheri, Maryam Ghaneialvar, Hori Haghani, Karimeh Khorshidi, Ali Shahbazi, Ali Salari, Sajjad Basic Clin Neurosci Research Paper INTRODUCTION: Oxidative stress plays a critical role in the pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior has not been clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city. METHODS: Fifty suicide attempters and 40 control subjects (volunteers) aged 18–35 years were studied in the current experiment. To consider the oxidant-antioxidant status, serum levels of Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide Dismutase (SOD), and the Total Antioxidant Capacity (TAC) were measured. RESULTS: Serum levels of SOD and TAC were significantly lower in the suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters compared to the control groups. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the control groups. CONCLUSION: The oxidative stress without MDA elevation, detected in suicide attempters, can be considered a biochemical hallmark in suicide behavior. Iranian Neuroscience Society 2021 2021-09-01 /pmc/articles/PMC8818118/ /pubmed/35173920 http://dx.doi.org/10.32598/bcn.2021.1917.1 Text en Copyright© 2021 Iranian Neuroscience Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Research Paper Oshnokhah, Mahin Bagheri, Maryam Ghaneialvar, Hori Haghani, Karimeh Khorshidi, Ali Shahbazi, Ali Salari, Sajjad The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity |
title | The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity |
title_full | The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity |
title_fullStr | The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity |
title_full_unstemmed | The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity |
title_short | The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity |
title_sort | role of oxidant-antioxidant status in suicide behavior in kurdish ethnicity |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818118/ https://www.ncbi.nlm.nih.gov/pubmed/35173920 http://dx.doi.org/10.32598/bcn.2021.1917.1 |
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