Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes

BACKGROUND: Although type 1 diabetes (T1D) is typically described as a T cell-mediated autoimmune disease, increasing evidence for a role of B cells has emerged. However, the pivotal disease-relevant B cell subset and its contribution to islet autoimmunity remain elusive. METHODS: The frequencies an...

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Detalles Bibliográficos
Autores principales: Ling, Qing, Shen, Lei, Zhang, Wei, Qu, DuoDuo, Wang, Hongdong, Wang, Bin, Liu, Yong, Lu, Jing, Zhu, Dalong, Bi, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818172/
https://www.ncbi.nlm.nih.gov/pubmed/35123388
http://dx.doi.org/10.1186/s10020-022-00447-y

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