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Schistosoma japonicum infection associated with membranous nephropathy: a case report

BACKGROUND: Schistosomiasis is one of the most contagious parasitic diseases affecting humans; however, glomerular injury is a rare complication mainly described with Schistosoma mansoni infection. We report a case of membranous nephropathy associated with Schistosoma japonicum infection in a Chines...

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Autores principales: Liao, Zhou-Ning, Tao, Li-Jian, Yin, Hong-ling, Xiao, Xiang-Chen, Lei, Min-Xiang, Peng, Zhang-Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818173/
https://www.ncbi.nlm.nih.gov/pubmed/35123391
http://dx.doi.org/10.1186/s12879-022-07092-0
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author Liao, Zhou-Ning
Tao, Li-Jian
Yin, Hong-ling
Xiao, Xiang-Chen
Lei, Min-Xiang
Peng, Zhang-Zhe
author_facet Liao, Zhou-Ning
Tao, Li-Jian
Yin, Hong-ling
Xiao, Xiang-Chen
Lei, Min-Xiang
Peng, Zhang-Zhe
author_sort Liao, Zhou-Ning
collection PubMed
description BACKGROUND: Schistosomiasis is one of the most contagious parasitic diseases affecting humans; however, glomerular injury is a rare complication mainly described with Schistosoma mansoni infection. We report a case of membranous nephropathy associated with Schistosoma japonicum infection in a Chinese man. CASE PRESENTATION: A 51-year-old Chinese male with a long history of S. japonicum infection presented to the hospital with a slowly progressing severe lower limb edema and foaming urine for over 5 months. Serum S. japonicumantigen test was positive and immunohistochemistry showed that the glomeruli were positive for the antigens. The renal pathologic diagnosis was stage III membranous nephropathy. The patient was treated with glucocorticoid, praziquantel, and an angiotensin-converting enzyme inhibitor. The edema in both lower limbs disappeared within 2 weeks, but his renal function declined progressively and proteinuria persisted after 5 months of therapy. CONCLUSIONS: Different classes of schistosomal glomerulopathy have completely different clinical manifestation and prognosis. Therefore, efforts should focus on alleviating symptoms, prevention, and early detection. S. japonicumassociated with membranous nephropathy may show a good curative effect and prognosis. However, it is necessary to monitor the renal function in such patients.
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spelling pubmed-88181732022-02-07 Schistosoma japonicum infection associated with membranous nephropathy: a case report Liao, Zhou-Ning Tao, Li-Jian Yin, Hong-ling Xiao, Xiang-Chen Lei, Min-Xiang Peng, Zhang-Zhe BMC Infect Dis Case Report BACKGROUND: Schistosomiasis is one of the most contagious parasitic diseases affecting humans; however, glomerular injury is a rare complication mainly described with Schistosoma mansoni infection. We report a case of membranous nephropathy associated with Schistosoma japonicum infection in a Chinese man. CASE PRESENTATION: A 51-year-old Chinese male with a long history of S. japonicum infection presented to the hospital with a slowly progressing severe lower limb edema and foaming urine for over 5 months. Serum S. japonicumantigen test was positive and immunohistochemistry showed that the glomeruli were positive for the antigens. The renal pathologic diagnosis was stage III membranous nephropathy. The patient was treated with glucocorticoid, praziquantel, and an angiotensin-converting enzyme inhibitor. The edema in both lower limbs disappeared within 2 weeks, but his renal function declined progressively and proteinuria persisted after 5 months of therapy. CONCLUSIONS: Different classes of schistosomal glomerulopathy have completely different clinical manifestation and prognosis. Therefore, efforts should focus on alleviating symptoms, prevention, and early detection. S. japonicumassociated with membranous nephropathy may show a good curative effect and prognosis. However, it is necessary to monitor the renal function in such patients. BioMed Central 2022-02-05 /pmc/articles/PMC8818173/ /pubmed/35123391 http://dx.doi.org/10.1186/s12879-022-07092-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Liao, Zhou-Ning
Tao, Li-Jian
Yin, Hong-ling
Xiao, Xiang-Chen
Lei, Min-Xiang
Peng, Zhang-Zhe
Schistosoma japonicum infection associated with membranous nephropathy: a case report
title Schistosoma japonicum infection associated with membranous nephropathy: a case report
title_full Schistosoma japonicum infection associated with membranous nephropathy: a case report
title_fullStr Schistosoma japonicum infection associated with membranous nephropathy: a case report
title_full_unstemmed Schistosoma japonicum infection associated with membranous nephropathy: a case report
title_short Schistosoma japonicum infection associated with membranous nephropathy: a case report
title_sort schistosoma japonicum infection associated with membranous nephropathy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818173/
https://www.ncbi.nlm.nih.gov/pubmed/35123391
http://dx.doi.org/10.1186/s12879-022-07092-0
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