Components of NOTCH Signaling for Uterine Cancer Patients' Prognosis

New molecular biomarkers that could have an independent prognostic value in endometrial cancer are currently under investigation. Recently, it was suggested that genetic changes in the Notch signaling pathway could be associated with the development of endometrial carcinoma. This study aimed to dete...

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Detalles Bibliográficos
Autores principales: Lachej, Nadezda, Dabkeviciene, Daiva, Simiene, Julija, Sabaliauskaite, Rasa, Jonusiene, Violeta, Brasiunas, Vytautas, Sasnauskiene, Ausra, Vaicekauskaite, Ieva, Brasiuniene, Birute, Kanopiene, Daiva, Suziedelis, Kestutis, Didziapetriene, Janina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818413/
https://www.ncbi.nlm.nih.gov/pubmed/35136410
http://dx.doi.org/10.1155/2022/8199306
Descripción
Sumario:New molecular biomarkers that could have an independent prognostic value in endometrial cancer are currently under investigation. Recently, it was suggested that genetic changes in the Notch signaling pathway could be associated with the development of endometrial carcinoma. This study aimed to determine the expression of the Notch signaling pathway components in tumour and adjacent normal uterine tissue and to evaluate their importance for the survival of uterine cancer patients. The present study was performed on uterine body samples collected from 109 patients and paired adjacent noncancerous endometrial tissue samples. Kaplan–Meier curves and Cox regression were used for survival analyses. Expression alterations of NOTCH2, NOTCH3, NOTCH4, JAG2, and HES1 were evaluated as independent and significant prognostic factors for uterine cancer patients.

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