Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation

The diffusion-limited reaction of nitric oxide (NO) and superoxide (O(2)(−)) produces peroxynitrite (ONOO(−)), a biological oxidant that has been implicated in a number of pathological conditions, including neurodegenerative disorders. We previously reported that incubation of PC12 cells with peroxy...

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Detalles Bibliográficos
Autores principales: Jandy, Megan, Noor, Asra, Nelson, Pascal, Dennys, Cassandra N., Karabinas, Isabella M., Pestoni, Jeanine C., Singh, Gautam D., Luc, Lam, Devyldere, Rachel, Perdomo, Nathalie, Mitchell, Catherine E., Adams, Levi, Fuse, Marisa A., Mendoza, Francine A., Marean-Reardon, Carrie L., Mehl, Ryan A., Estevez, Alvaro G., Franco, Maria Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818572/
https://www.ncbi.nlm.nih.gov/pubmed/35121403
http://dx.doi.org/10.1016/j.redox.2022.102247

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