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Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin

BACKGROUND: Muscle weakness is a frequently occurring complication of sepsis, associated with increased morbidity and mortality. Interestingly, obesity attenuates sepsis‐induced muscle wasting and weakness. As the adipokine leptin is strongly elevated in obesity and has been shown to affect muscle h...

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Detalles Bibliográficos
Autores principales: Vankrunkelsven, Wouter, Derde, Sarah, Gunst, Jan, Vander Perre, Sarah, Declerck, Emiel, Pauwels, Lies, Derese, Inge, Van den Berghe, Greet, Langouche, Lies
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818596/
https://www.ncbi.nlm.nih.gov/pubmed/34994068
http://dx.doi.org/10.1002/jcsm.12904