Cargando…

The contributory role of vascular health in age‐related anabolic resistance

Sarcopenia, or the age‐related loss of skeletal muscle mass and function, is an increasingly prevalent condition that contributes to reduced quality of life, morbidity, and mortality in older adults. Older adults display blunted anabolic responses to otherwise anabolic stimuli—a phenomenon that has...

Descripción completa

Detalles Bibliográficos
Autores principales: Banks, Nile F., Rogers, Emily M., Church, David D., Ferrando, Arny A., Jenkins, Nathaniel D.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818606/
https://www.ncbi.nlm.nih.gov/pubmed/34951146
http://dx.doi.org/10.1002/jcsm.12898
_version_ 1784645860130291712
author Banks, Nile F.
Rogers, Emily M.
Church, David D.
Ferrando, Arny A.
Jenkins, Nathaniel D.M.
author_facet Banks, Nile F.
Rogers, Emily M.
Church, David D.
Ferrando, Arny A.
Jenkins, Nathaniel D.M.
author_sort Banks, Nile F.
collection PubMed
description Sarcopenia, or the age‐related loss of skeletal muscle mass and function, is an increasingly prevalent condition that contributes to reduced quality of life, morbidity, and mortality in older adults. Older adults display blunted anabolic responses to otherwise anabolic stimuli—a phenomenon that has been termed anabolic resistance (AR)—which is likely a casual factor in sarcopenia development. AR is multifaceted, but historically much of the mechanistic focus has been on signalling impairments, and less focus has been placed on the role of the vasculature in postprandial protein kinetics. The vascular endothelium plays an indispensable role in regulating vascular tone and blood flow, and age‐related impairments in vascular health may impede nutrient‐stimulated vasodilation and subsequently the ability to deliver nutrients (e.g. amino acids) to skeletal muscle. Although the majority of data has been obtained studying younger adults, the relatively limited data on the effect of blood flow on protein kinetics in older adults suggest that vasodilatory function, especially of the microvasculature, strongly influences the muscle protein synthetic response to amino acid feedings. In this narrative review, we examine evidence of AR in older adults following amino acid and mixed meal consumption, examine the evidence linking vascular dysfunction and insulin resistance to age‐related AR, review the influence of nitric oxide and endothelin‐1 on age‐related vascular dysfunction as it relates to AR, briefly review the potential causal role of arterial stiffness in promoting skeletal muscle microvascular dysfunction and AR, and provide a brief overview and future considerations for research examining age‐related AR.
format Online
Article
Text
id pubmed-8818606
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-88186062022-02-09 The contributory role of vascular health in age‐related anabolic resistance Banks, Nile F. Rogers, Emily M. Church, David D. Ferrando, Arny A. Jenkins, Nathaniel D.M. J Cachexia Sarcopenia Muscle Reviews Sarcopenia, or the age‐related loss of skeletal muscle mass and function, is an increasingly prevalent condition that contributes to reduced quality of life, morbidity, and mortality in older adults. Older adults display blunted anabolic responses to otherwise anabolic stimuli—a phenomenon that has been termed anabolic resistance (AR)—which is likely a casual factor in sarcopenia development. AR is multifaceted, but historically much of the mechanistic focus has been on signalling impairments, and less focus has been placed on the role of the vasculature in postprandial protein kinetics. The vascular endothelium plays an indispensable role in regulating vascular tone and blood flow, and age‐related impairments in vascular health may impede nutrient‐stimulated vasodilation and subsequently the ability to deliver nutrients (e.g. amino acids) to skeletal muscle. Although the majority of data has been obtained studying younger adults, the relatively limited data on the effect of blood flow on protein kinetics in older adults suggest that vasodilatory function, especially of the microvasculature, strongly influences the muscle protein synthetic response to amino acid feedings. In this narrative review, we examine evidence of AR in older adults following amino acid and mixed meal consumption, examine the evidence linking vascular dysfunction and insulin resistance to age‐related AR, review the influence of nitric oxide and endothelin‐1 on age‐related vascular dysfunction as it relates to AR, briefly review the potential causal role of arterial stiffness in promoting skeletal muscle microvascular dysfunction and AR, and provide a brief overview and future considerations for research examining age‐related AR. John Wiley and Sons Inc. 2021-12-23 2022-02 /pmc/articles/PMC8818606/ /pubmed/34951146 http://dx.doi.org/10.1002/jcsm.12898 Text en © 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Banks, Nile F.
Rogers, Emily M.
Church, David D.
Ferrando, Arny A.
Jenkins, Nathaniel D.M.
The contributory role of vascular health in age‐related anabolic resistance
title The contributory role of vascular health in age‐related anabolic resistance
title_full The contributory role of vascular health in age‐related anabolic resistance
title_fullStr The contributory role of vascular health in age‐related anabolic resistance
title_full_unstemmed The contributory role of vascular health in age‐related anabolic resistance
title_short The contributory role of vascular health in age‐related anabolic resistance
title_sort contributory role of vascular health in age‐related anabolic resistance
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818606/
https://www.ncbi.nlm.nih.gov/pubmed/34951146
http://dx.doi.org/10.1002/jcsm.12898
work_keys_str_mv AT banksnilef thecontributoryroleofvascularhealthinagerelatedanabolicresistance
AT rogersemilym thecontributoryroleofvascularhealthinagerelatedanabolicresistance
AT churchdavidd thecontributoryroleofvascularhealthinagerelatedanabolicresistance
AT ferrandoarnya thecontributoryroleofvascularhealthinagerelatedanabolicresistance
AT jenkinsnathanieldm thecontributoryroleofvascularhealthinagerelatedanabolicresistance
AT banksnilef contributoryroleofvascularhealthinagerelatedanabolicresistance
AT rogersemilym contributoryroleofvascularhealthinagerelatedanabolicresistance
AT churchdavidd contributoryroleofvascularhealthinagerelatedanabolicresistance
AT ferrandoarnya contributoryroleofvascularhealthinagerelatedanabolicresistance
AT jenkinsnathanieldm contributoryroleofvascularhealthinagerelatedanabolicresistance