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Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model

Speckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and ventricular functional parameters during Chagas disease (CD) natural history in an animal model. 37 Syrian hamsters were inocul...

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Autores principales: Ribeiro, Fernando Fonseca França, Moreira, Henrique Turin, de Barros-Filho, Antônio Carlos Leite, Tanaka, Denise M., Fabricio, Camila G., Oliveira, Luciano F. L., Prado, Cibele M., Simões, Marcus V., Schmidt, André, Maciel, Benedito C., Marin-Neto, José A., Romano, Minna Moreira Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818632/
https://www.ncbi.nlm.nih.gov/pubmed/34535853
http://dx.doi.org/10.1007/s10554-021-02379-w
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author Ribeiro, Fernando Fonseca França
Moreira, Henrique Turin
de Barros-Filho, Antônio Carlos Leite
Tanaka, Denise M.
Fabricio, Camila G.
Oliveira, Luciano F. L.
Prado, Cibele M.
Simões, Marcus V.
Schmidt, André
Maciel, Benedito C.
Marin-Neto, José A.
Romano, Minna Moreira Dias
author_facet Ribeiro, Fernando Fonseca França
Moreira, Henrique Turin
de Barros-Filho, Antônio Carlos Leite
Tanaka, Denise M.
Fabricio, Camila G.
Oliveira, Luciano F. L.
Prado, Cibele M.
Simões, Marcus V.
Schmidt, André
Maciel, Benedito C.
Marin-Neto, José A.
Romano, Minna Moreira Dias
author_sort Ribeiro, Fernando Fonseca França
collection PubMed
description Speckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and ventricular functional parameters during Chagas disease (CD) natural history in an animal model. 37 Syrian hamsters were inoculated intraperitoneally with Trypanosoma cruzi (Chagas) and 20 with saline (Control). Echocardiography was performed before the infection (baseline), at 1 month (acute phase), 4, 6, and 8 months (chronic phase) using Vevo 2100 (Fujifilm Inc.) ultrasound system. Left ventricular end-diastolic diameter, Left ventricular end-systolic diameter (LVESD), Left ventricular ejection fraction (LVEF), Global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were evaluated. Tricuspid annular plane systolic excursion (TAPSE) was used to assess right ventricular function. At 8 months, animals were euthanized and LV myocardial samples were analyzed for quantitation of inflammation and fibrosis. LVEF decreased over time in Chagas group and a difference from Control was detected at 6 months (p-value of groups#time interaction = 0.005). There was a pronounced decrease in GLS, GCS and TAPSE in Chagas group (p-value of groups#time interaction = 0.003 for GLS, < 0.001 for GCS and < 0.009 for TAPSE vs Control) since the first month. LVESD, LVEF and GLS were significantly correlated to the number of inflammatory cells (r = 0.41, p = 0.046; r = − 0.42, p = 0.042; r = 0.41, p = 0.047) but not to fibrosis. In the Syrian hamster model of CD STE parameters (GLS and GCS) showed an early decrease. Changes in LVEF, LVESD, and GLS were correlated to myocardial inflammation but not to fibrosis.
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spelling pubmed-88186322022-02-22 Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model Ribeiro, Fernando Fonseca França Moreira, Henrique Turin de Barros-Filho, Antônio Carlos Leite Tanaka, Denise M. Fabricio, Camila G. Oliveira, Luciano F. L. Prado, Cibele M. Simões, Marcus V. Schmidt, André Maciel, Benedito C. Marin-Neto, José A. Romano, Minna Moreira Dias Int J Cardiovasc Imaging Original Paper Speckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and ventricular functional parameters during Chagas disease (CD) natural history in an animal model. 37 Syrian hamsters were inoculated intraperitoneally with Trypanosoma cruzi (Chagas) and 20 with saline (Control). Echocardiography was performed before the infection (baseline), at 1 month (acute phase), 4, 6, and 8 months (chronic phase) using Vevo 2100 (Fujifilm Inc.) ultrasound system. Left ventricular end-diastolic diameter, Left ventricular end-systolic diameter (LVESD), Left ventricular ejection fraction (LVEF), Global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were evaluated. Tricuspid annular plane systolic excursion (TAPSE) was used to assess right ventricular function. At 8 months, animals were euthanized and LV myocardial samples were analyzed for quantitation of inflammation and fibrosis. LVEF decreased over time in Chagas group and a difference from Control was detected at 6 months (p-value of groups#time interaction = 0.005). There was a pronounced decrease in GLS, GCS and TAPSE in Chagas group (p-value of groups#time interaction = 0.003 for GLS, < 0.001 for GCS and < 0.009 for TAPSE vs Control) since the first month. LVESD, LVEF and GLS were significantly correlated to the number of inflammatory cells (r = 0.41, p = 0.046; r = − 0.42, p = 0.042; r = 0.41, p = 0.047) but not to fibrosis. In the Syrian hamster model of CD STE parameters (GLS and GCS) showed an early decrease. Changes in LVEF, LVESD, and GLS were correlated to myocardial inflammation but not to fibrosis. Springer Netherlands 2021-09-18 2022 /pmc/articles/PMC8818632/ /pubmed/34535853 http://dx.doi.org/10.1007/s10554-021-02379-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Ribeiro, Fernando Fonseca França
Moreira, Henrique Turin
de Barros-Filho, Antônio Carlos Leite
Tanaka, Denise M.
Fabricio, Camila G.
Oliveira, Luciano F. L.
Prado, Cibele M.
Simões, Marcus V.
Schmidt, André
Maciel, Benedito C.
Marin-Neto, José A.
Romano, Minna Moreira Dias
Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model
title Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model
title_full Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model
title_fullStr Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model
title_full_unstemmed Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model
title_short Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model
title_sort prospective analysis of myocardial strain through the evolution of chagas disease in the hamster animal model
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818632/
https://www.ncbi.nlm.nih.gov/pubmed/34535853
http://dx.doi.org/10.1007/s10554-021-02379-w
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