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Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions,...

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Autores principales: Soares, Madu N., Eggelbusch, Moritz, Naddaf, Elie, Gerrits, Karin H. L., van der Schaaf, Marike, van den Borst, Bram, Wiersinga, W. Joost, van Vugt, Michele, Weijs, Peter J.M., Murray, Andrew J., Wüst, Rob C.I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818659/
https://www.ncbi.nlm.nih.gov/pubmed/34997689
http://dx.doi.org/10.1002/jcsm.12896
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author Soares, Madu N.
Eggelbusch, Moritz
Naddaf, Elie
Gerrits, Karin H. L.
van der Schaaf, Marike
van den Borst, Bram
Wiersinga, W. Joost
van Vugt, Michele
Weijs, Peter J.M.
Murray, Andrew J.
Wüst, Rob C.I.
author_facet Soares, Madu N.
Eggelbusch, Moritz
Naddaf, Elie
Gerrits, Karin H. L.
van der Schaaf, Marike
van den Borst, Bram
Wiersinga, W. Joost
van Vugt, Michele
Weijs, Peter J.M.
Murray, Andrew J.
Wüst, Rob C.I.
author_sort Soares, Madu N.
collection PubMed
description Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post‐viral fatigue syndrome. Patients with severe Covid‐19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid‐19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post‐intensive care unit (ICU) syndrome and ICU‐acquired weakness and likely explain a substantial part of Covid‐19‐acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS‐CoV)‐2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS‐CoV‐2‐specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid‐19 and PASC.
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spelling pubmed-88186592022-02-09 Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19 Soares, Madu N. Eggelbusch, Moritz Naddaf, Elie Gerrits, Karin H. L. van der Schaaf, Marike van den Borst, Bram Wiersinga, W. Joost van Vugt, Michele Weijs, Peter J.M. Murray, Andrew J. Wüst, Rob C.I. J Cachexia Sarcopenia Muscle Reviews Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post‐viral fatigue syndrome. Patients with severe Covid‐19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid‐19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post‐intensive care unit (ICU) syndrome and ICU‐acquired weakness and likely explain a substantial part of Covid‐19‐acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS‐CoV)‐2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS‐CoV‐2‐specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid‐19 and PASC. John Wiley and Sons Inc. 2022-01-07 2022-02 /pmc/articles/PMC8818659/ /pubmed/34997689 http://dx.doi.org/10.1002/jcsm.12896 Text en © 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Soares, Madu N.
Eggelbusch, Moritz
Naddaf, Elie
Gerrits, Karin H. L.
van der Schaaf, Marike
van den Borst, Bram
Wiersinga, W. Joost
van Vugt, Michele
Weijs, Peter J.M.
Murray, Andrew J.
Wüst, Rob C.I.
Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
title Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
title_full Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
title_fullStr Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
title_full_unstemmed Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
title_short Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
title_sort skeletal muscle alterations in patients with acute covid‐19 and post‐acute sequelae of covid‐19
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818659/
https://www.ncbi.nlm.nih.gov/pubmed/34997689
http://dx.doi.org/10.1002/jcsm.12896
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