Extracellular lipidome change by an SGLT2 inhibitor, luseogliflozin, contributes to prevent skeletal muscle atrophy in db/db mice

BACKGROUND: Diabetes mellitus increases the excretion of urinary glucose from the renal glomeruli due to elevated blood glucose levels. In the renal tubules, SGLT2 is expressed and reabsorbs the excreted urinary glucose. In the pathogenesis of diabetes mellitus, glucose reabsorption by SGLT2 is incr...

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Detalles Bibliográficos
Autores principales: Bamba, Ryo, Okamura, Takuro, Hashimoto, Yoshitaka, Majima, Saori, Senmaru, Takafumi, Ushigome, Emi, Nakanishi, Naoko, Asano, Mai, Yamazaki, Masahiro, Takakuwa, Hiroshi, Hamaguchi, Masahide, Fukui, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles: Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818690/
https://www.ncbi.nlm.nih.gov/pubmed/34854254
http://dx.doi.org/10.1002/jcsm.12814

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