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Safety Profile of Nutraceuticals Rich in Coumarins: An Update
Coumarins are a family of benzopyrones largely distributed in the natural kingdom, being present in the seeds, fruits, flowers, or roots of various plant species. Natural coumarin compounds are found in significant concentrations in some herbs or spices used as nutraceuticals, but they are also pres...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818878/ https://www.ncbi.nlm.nih.gov/pubmed/35140615 http://dx.doi.org/10.3389/fphar.2022.803338 |
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author | Heghes, Simona Codruta Vostinaru, Oliviu Mogosan, Cristina Miere, Doina Iuga, Cristina Adela Filip, Lorena |
author_facet | Heghes, Simona Codruta Vostinaru, Oliviu Mogosan, Cristina Miere, Doina Iuga, Cristina Adela Filip, Lorena |
author_sort | Heghes, Simona Codruta |
collection | PubMed |
description | Coumarins are a family of benzopyrones largely distributed in the natural kingdom, being present in the seeds, fruits, flowers, or roots of various plant species. Natural coumarin compounds are found in significant concentrations in some herbs or spices used as nutraceuticals, but they are also present in cosmetics or household products, due to their pleasant odor. Therefore, an accidental exposure to high doses of coumarins, could lead to the development of harmful effects in some patients. This review summarizes the latest published data from preclinical and clinical studies with natural coumarins, focused on the investigation of general and specific toxicity, with the aim of a better understanding of the safety profile of these valuable compounds. Regulatory aspects concerning the use of natural coumarins in several world regions are also reviewed. |
format | Online Article Text |
id | pubmed-8818878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88188782022-02-08 Safety Profile of Nutraceuticals Rich in Coumarins: An Update Heghes, Simona Codruta Vostinaru, Oliviu Mogosan, Cristina Miere, Doina Iuga, Cristina Adela Filip, Lorena Front Pharmacol Pharmacology Coumarins are a family of benzopyrones largely distributed in the natural kingdom, being present in the seeds, fruits, flowers, or roots of various plant species. Natural coumarin compounds are found in significant concentrations in some herbs or spices used as nutraceuticals, but they are also present in cosmetics or household products, due to their pleasant odor. Therefore, an accidental exposure to high doses of coumarins, could lead to the development of harmful effects in some patients. This review summarizes the latest published data from preclinical and clinical studies with natural coumarins, focused on the investigation of general and specific toxicity, with the aim of a better understanding of the safety profile of these valuable compounds. Regulatory aspects concerning the use of natural coumarins in several world regions are also reviewed. Frontiers Media S.A. 2022-01-24 /pmc/articles/PMC8818878/ /pubmed/35140615 http://dx.doi.org/10.3389/fphar.2022.803338 Text en Copyright © 2022 Heghes, Vostinaru, Mogosan, Miere, Iuga and Filip. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Heghes, Simona Codruta Vostinaru, Oliviu Mogosan, Cristina Miere, Doina Iuga, Cristina Adela Filip, Lorena Safety Profile of Nutraceuticals Rich in Coumarins: An Update |
title | Safety Profile of Nutraceuticals Rich in Coumarins: An Update |
title_full | Safety Profile of Nutraceuticals Rich in Coumarins: An Update |
title_fullStr | Safety Profile of Nutraceuticals Rich in Coumarins: An Update |
title_full_unstemmed | Safety Profile of Nutraceuticals Rich in Coumarins: An Update |
title_short | Safety Profile of Nutraceuticals Rich in Coumarins: An Update |
title_sort | safety profile of nutraceuticals rich in coumarins: an update |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818878/ https://www.ncbi.nlm.nih.gov/pubmed/35140615 http://dx.doi.org/10.3389/fphar.2022.803338 |
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