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Safety Profile of Nutraceuticals Rich in Coumarins: An Update

Coumarins are a family of benzopyrones largely distributed in the natural kingdom, being present in the seeds, fruits, flowers, or roots of various plant species. Natural coumarin compounds are found in significant concentrations in some herbs or spices used as nutraceuticals, but they are also pres...

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Autores principales: Heghes, Simona Codruta, Vostinaru, Oliviu, Mogosan, Cristina, Miere, Doina, Iuga, Cristina Adela, Filip, Lorena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818878/
https://www.ncbi.nlm.nih.gov/pubmed/35140615
http://dx.doi.org/10.3389/fphar.2022.803338
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author Heghes, Simona Codruta
Vostinaru, Oliviu
Mogosan, Cristina
Miere, Doina
Iuga, Cristina Adela
Filip, Lorena
author_facet Heghes, Simona Codruta
Vostinaru, Oliviu
Mogosan, Cristina
Miere, Doina
Iuga, Cristina Adela
Filip, Lorena
author_sort Heghes, Simona Codruta
collection PubMed
description Coumarins are a family of benzopyrones largely distributed in the natural kingdom, being present in the seeds, fruits, flowers, or roots of various plant species. Natural coumarin compounds are found in significant concentrations in some herbs or spices used as nutraceuticals, but they are also present in cosmetics or household products, due to their pleasant odor. Therefore, an accidental exposure to high doses of coumarins, could lead to the development of harmful effects in some patients. This review summarizes the latest published data from preclinical and clinical studies with natural coumarins, focused on the investigation of general and specific toxicity, with the aim of a better understanding of the safety profile of these valuable compounds. Regulatory aspects concerning the use of natural coumarins in several world regions are also reviewed.
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spelling pubmed-88188782022-02-08 Safety Profile of Nutraceuticals Rich in Coumarins: An Update Heghes, Simona Codruta Vostinaru, Oliviu Mogosan, Cristina Miere, Doina Iuga, Cristina Adela Filip, Lorena Front Pharmacol Pharmacology Coumarins are a family of benzopyrones largely distributed in the natural kingdom, being present in the seeds, fruits, flowers, or roots of various plant species. Natural coumarin compounds are found in significant concentrations in some herbs or spices used as nutraceuticals, but they are also present in cosmetics or household products, due to their pleasant odor. Therefore, an accidental exposure to high doses of coumarins, could lead to the development of harmful effects in some patients. This review summarizes the latest published data from preclinical and clinical studies with natural coumarins, focused on the investigation of general and specific toxicity, with the aim of a better understanding of the safety profile of these valuable compounds. Regulatory aspects concerning the use of natural coumarins in several world regions are also reviewed. Frontiers Media S.A. 2022-01-24 /pmc/articles/PMC8818878/ /pubmed/35140615 http://dx.doi.org/10.3389/fphar.2022.803338 Text en Copyright © 2022 Heghes, Vostinaru, Mogosan, Miere, Iuga and Filip. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Heghes, Simona Codruta
Vostinaru, Oliviu
Mogosan, Cristina
Miere, Doina
Iuga, Cristina Adela
Filip, Lorena
Safety Profile of Nutraceuticals Rich in Coumarins: An Update
title Safety Profile of Nutraceuticals Rich in Coumarins: An Update
title_full Safety Profile of Nutraceuticals Rich in Coumarins: An Update
title_fullStr Safety Profile of Nutraceuticals Rich in Coumarins: An Update
title_full_unstemmed Safety Profile of Nutraceuticals Rich in Coumarins: An Update
title_short Safety Profile of Nutraceuticals Rich in Coumarins: An Update
title_sort safety profile of nutraceuticals rich in coumarins: an update
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818878/
https://www.ncbi.nlm.nih.gov/pubmed/35140615
http://dx.doi.org/10.3389/fphar.2022.803338
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