Cargando…

ATG16L1 is a Potential Prognostic Biomarker and Immune Signature for Osteosarcoma: A Study Based on Bulk RNA and Single-Cell RNA-Sequencing

BACKGROUND: Osteosarcoma is a common solid malignancy of the bone in children and adolescents, and its metastasis and recurrence are the principal causes of poor treatment outcomes. METHODS: Autophagy-related genes were used to cluster osteosarcoma patients by consensus clustering analysis using the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Zhaojie, Luo, Kai, Liu, Yun, Liao, Shijie, He, Juliang, He, Mingwei, Xie, Tianyu, Jiang, Xiaohong, Li, Boxiang, Liu, Huijiang, Huang, Qian, Tang, Haijun, Feng, Wenyu, Zhan, Xinli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818976/ https://www.ncbi.nlm.nih.gov/pubmed/35140506 http://dx.doi.org/10.2147/IJGM.S341879

Ejemplares similares

The regulatory mechanism of LncRNA-mediated ceRNA network in osteosarcoma
por: Lin, Chengsen, et al.
Publicado: (2022)

Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of Bone
por: Feng, Wenyu, et al.
Publicado: (2021)

Long non-coding RNA and circular RNA and coding RNA profiling of plasma exosomes of osteosarcoma by RNA seq
por: Liu, Yun, et al.
Publicado: (2023)

Diagnosis and treatment of primary hyperparathyroidism with pathological fracture of the limbs: A retrospective observational study
por: Liu, Huijiang, et al.
Publicado: (2022)

Single-Cell Transcriptomics Reveals the Complexity of the Tumor Microenvironment of Treatment-Naive Osteosarcoma
por: Liu, Yun, et al.
Publicado: (2021)

Corrigendum: Single-cell transcriptomics reveals the complexity of the tumor microenvironment of treatment-naive osteosarcoma
por: Liu, Yun, et al.
Publicado: (2022)

Trends of denosumab-related publications in web of science
por: Jiang, Xiaohong, et al.
Publicado: (2023)

Validation the role of desmocollin-2 in osteosarcoma based on single cell and bulk RNA seq and experimental analyses
por: Zeng, Jiaxing, et al.
Publicado: (2023)

MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma
por: Chen, Ren, et al.
Publicado: (2017)

Significance of the neutrophil-to-lymphocyte ratio in predicting the response to neoadjuvant chemotherapy in extremity osteosarcoma: a multicentre retrospective study
por: Tang, Haijun, et al.
Publicado: (2022)

Construction of a transcription factor-miRNA-mRNA interactive network elucidates underlying pathogenesis for osteosarcoma and validation by qRT-PCR
por: Tang, Fuxing, et al.
Publicado: (2022)

STAT3 and its targeting inhibitors in osteosarcoma
por: Liu, Yun, et al.
Publicado: (2020)

Isoliensinine Suppresses Osteoclast Formation Through NF-κB Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss
por: Liu, Huijiang, et al.
Publicado: (2022)

High GNG4 predicts adverse prognosis for osteosarcoma: Bioinformatics prediction and experimental verification
por: Jiang, Xiaohong, et al.
Publicado: (2023)

A novel molecular signature for predicting prognosis and immunotherapy response in osteosarcoma based on tumor-infiltrating cell marker genes
por: Tang, Haijun, et al.
Publicado: (2023)

Suppressive effect of microRNA-138 on the proliferation and invasion of osteosarcoma cells via targeting SIRT1
por: Yuan, Zhenchao, et al.
Publicado: (2017)

The lncRNA HOTAIR regulates autophagy and affects lipopolysaccharide‐induced acute lung injury through the miR‐17‐5p/ATG2/ATG7/ATG16 axis
por: Li, Yujun, et al.
Publicado: (2021)

Interaction gene set between osteoclasts and regulatory CD4(+) T cells can accurately predict the prognosis of patients with osteosarcoma
por: Li, Feicui, et al.
Publicado: (2023)

[Retracted] Suppressive effect of microRNA‑138 on the proliferation and invasion of osteosarcoma cells via targeting SIRT1
por: Yuan, Zhenchao, et al.
Publicado: (2023)

MicroRNA-106a Inhibits Autophagy Process and Antimicrobial Responses by Targeting ULK1, ATG7, and ATG16L1 During Mycobacterial Infection
por: Liu, Kunmei, et al.
Publicado: (2021)

Long Noncoding RNA CCDC144NL-AS1 Promotes the Oncogenicity of Osteosarcoma by Acting as a Molecular Sponge for microRNA-490-3p and Thereby Increasing HMGA2 Expression
por: He, Juliang, et al.
Publicado: (2021)

ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy
por: Wible, Daric J., et al.
Publicado: (2019)

Identification of ATG7 as a Regulator of Proferroptosis and Oxidative Stress in Osteosarcoma
por: Jiang, Runyi, et al.
Publicado: (2022)

Elaboration and validation of a prognostic signature associated with disulfidoptosis in lung adenocarcinoma, consolidated with integration of single-cell RNA sequencing and bulk RNA sequencing techniques
por: He, Dabao, et al.
Publicado: (2023)

Long Noncoding RNA MALAT1 Interacts with miR-124-3p to Modulate Osteosarcoma Progression by Targeting SphK1
por: Liu, Bin, et al.
Publicado: (2021)

The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
por: Xiong, Qiuhong, et al.
Publicado: (2015)

RNA(seq) and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16
por: Xiong, Qiuhong, et al.
Publicado: (2021)

TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A
por: Sun, Yizhe, et al.
Publicado: (2017)

Correction to: RNA(seq) and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16
por: Xiong, Qiuhong, et al.
Publicado: (2021)

Integrated miRNA-mRNA network revealing the key molecular characteristics of ossification of the posterior longitudinal ligament
por: Xu, Guoyong, et al.
Publicado: (2020)

Identification of cuproptosis-related lncRNA prognostic signature for osteosarcoma
por: Liu, Binfeng, et al.
Publicado: (2022)

Crystallization of the Atg12–Atg5 conjugate bound to Atg16 by the free-interface diffusion method
por: Noda, Nobuo N., et al.
Publicado: (2008)

Establishment of immune prognostic signature and analysis of prospective molecular mechanisms in childhood osteosarcoma patients
por: Zhang, Zide, et al.
Publicado: (2020)

Identification of the Immune Status of Hypertrophic Cardiomyopathy by Integrated Analysis of Bulk- and Single-Cell RNA Sequencing Data
por: Zhao, Wei, et al.
Publicado: (2022)

microRNA-20a Inhibits Autophagic Process by Targeting ATG7 and ATG16L1 and Favors Mycobacterial Survival in Macrophage Cells
por: Guo, Le, et al.
Publicado: (2016)

Combining bulk RNA-sequencing and single-cell RNA-sequencing data to reveal the immune microenvironment and metabolic pattern of osteosarcoma
por: Huang, Ruichao, et al.
Publicado: (2022)

Molecular Characterization and Functional Analysis of Three Autophagy Genes, BxATG5, BxATG9, and BxATG16, in Bursaphelenchus xylophilus
por: Liu, Hong-Bin, et al.
Publicado: (2019)

MicroRNA 223 Targeting ATG16L1 Affects Microglial Autophagy in the Kainic Acid Model of Temporal Lobe Epilepsy
por: He, Zhuoyi, et al.
Publicado: (2021)

A new model of preoperative systemic inflammatory markers predicting overall survival of osteosarcoma: a multicenter retrospective study
por: Huang, Xianying, et al.
Publicado: (2022)

Occipito-cervical fusion following gross total resection for the treatment of spinal extramedullary tumors in craniocervical junction: a retrospective case series
por: Jiang, Hua, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_av7qa9nvd9vfig4v011mru68b6