Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage

We report a vitreous amyloidosis patient with white vitreous opacities (footplates) adhering to the posterior lens capsule. A positive Congo-red stain and transthyretin (TTR) Lys55Asn mutation confirmed the diagnosis of vitreous amyloidosis. Optical coherence tomography (OCT) revealed fern-like mate...

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Autores principales: Xu, Qing, Wang, Xinting, Zhang, Zhengpei, Li, Jie, Liu, Haiyang, Ji, Sujuan, Qiao, Lei, Gong, Chaoju, Feng, Ruifang, Li, Suyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818993/
https://www.ncbi.nlm.nih.gov/pubmed/35141244
http://dx.doi.org/10.3389/fmed.2021.797223
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author Xu, Qing
Wang, Xinting
Zhang, Zhengpei
Li, Jie
Liu, Haiyang
Ji, Sujuan
Qiao, Lei
Gong, Chaoju
Feng, Ruifang
Li, Suyan
author_facet Xu, Qing
Wang, Xinting
Zhang, Zhengpei
Li, Jie
Liu, Haiyang
Ji, Sujuan
Qiao, Lei
Gong, Chaoju
Feng, Ruifang
Li, Suyan
author_sort Xu, Qing
collection PubMed
description We report a vitreous amyloidosis patient with white vitreous opacities (footplates) adhering to the posterior lens capsule. A positive Congo-red stain and transthyretin (TTR) Lys55Asn mutation confirmed the diagnosis of vitreous amyloidosis. Optical coherence tomography (OCT) revealed fern-like material adhering to the the posterior pole retinal surface in both eyes. Visual acuity significantly improved after the first vitrectomy, but vitreous opacities recurred 4 years later. The patient appeared to have aggravated sensorimotor neuropathy and severe autonomic dysfunction at the same time. He developed intraoperative suprachoroidal hemorrhage during the second vitrectomy.
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spelling pubmed-88189932022-02-08 Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage Xu, Qing Wang, Xinting Zhang, Zhengpei Li, Jie Liu, Haiyang Ji, Sujuan Qiao, Lei Gong, Chaoju Feng, Ruifang Li, Suyan Front Med (Lausanne) Medicine We report a vitreous amyloidosis patient with white vitreous opacities (footplates) adhering to the posterior lens capsule. A positive Congo-red stain and transthyretin (TTR) Lys55Asn mutation confirmed the diagnosis of vitreous amyloidosis. Optical coherence tomography (OCT) revealed fern-like material adhering to the the posterior pole retinal surface in both eyes. Visual acuity significantly improved after the first vitrectomy, but vitreous opacities recurred 4 years later. The patient appeared to have aggravated sensorimotor neuropathy and severe autonomic dysfunction at the same time. He developed intraoperative suprachoroidal hemorrhage during the second vitrectomy. Frontiers Media S.A. 2022-01-24 /pmc/articles/PMC8818993/ /pubmed/35141244 http://dx.doi.org/10.3389/fmed.2021.797223 Text en Copyright © 2022 Xu, Wang, Zhang, Li, Liu, Ji, Qiao, Gong, Feng and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Xu, Qing
Wang, Xinting
Zhang, Zhengpei
Li, Jie
Liu, Haiyang
Ji, Sujuan
Qiao, Lei
Gong, Chaoju
Feng, Ruifang
Li, Suyan
Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage
title Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage
title_full Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage
title_fullStr Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage
title_full_unstemmed Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage
title_short Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage
title_sort case report: vitreous amyloidosis caused by a ttr lys55asn mutation with intraoperative suprachoroidal hemorrhage
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818993/
https://www.ncbi.nlm.nih.gov/pubmed/35141244
http://dx.doi.org/10.3389/fmed.2021.797223
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