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IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington disease mouse model
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB pathway is an essential regulator of metabolism, we investigat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819015/ https://www.ncbi.nlm.nih.gov/pubmed/35146388 http://dx.doi.org/10.1016/j.isci.2022.103771 |