MCU (mitochondrial Ca(2+) uniporter) makes the calcium go round

Store-operated Ca(2+) entry (SOCE) is a major mechanism controlling Ca(2+) signaling and Ca(2+)-dependent functions and has been implicated in immunity, cancer, and organ development. SOCE-dependent cytosolic Ca(2+) signals are affected by mitochondrial Ca(2+) transport through several competing mec...

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Detalles Bibliográficos
Autores principales: Walters, Grant C., Usachev, Yuriy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819027/
https://www.ncbi.nlm.nih.gov/pubmed/35051417
http://dx.doi.org/10.1016/j.jbc.2022.101604
Descripción
Sumario:Store-operated Ca(2+) entry (SOCE) is a major mechanism controlling Ca(2+) signaling and Ca(2+)-dependent functions and has been implicated in immunity, cancer, and organ development. SOCE-dependent cytosolic Ca(2+) signals are affected by mitochondrial Ca(2+) transport through several competing mechanisms. However, how these mechanisms interact in shaping Ca(2+) dynamics and regulating Ca(2+)-dependent functions remains unclear. In a recent issue, Yoast et al. shed light on these questions by defining multiple roles of the mitochondrial Ca(2+) uniporter in regulating SOCE, Ca(2+) dynamics, transcription, and lymphocyte activation.

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