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Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study

BACKGROUND: Constipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two. Most of the studies on consti...

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Autores principales: Wang, Fei, Fei, Min, Hu, Wen-Zheng, Wang, Xiao-Dan, Liu, Shuai, Zeng, Yan, Zhang, Jin-Hong, Lv, Yang, Niu, Jian-ping, Meng, Xin-ling, Cai, Pan, Li, Yang, Gang, Bao-zhi, You, Yong, Lv, Yan, Ji, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819140/
https://www.ncbi.nlm.nih.gov/pubmed/35140587
http://dx.doi.org/10.3389/fnins.2021.821654
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author Wang, Fei
Fei, Min
Hu, Wen-Zheng
Wang, Xiao-Dan
Liu, Shuai
Zeng, Yan
Zhang, Jin-Hong
Lv, Yang
Niu, Jian-ping
Meng, Xin-ling
Cai, Pan
Li, Yang
Gang, Bao-zhi
You, Yong
Lv, Yan
Ji, Yong
author_facet Wang, Fei
Fei, Min
Hu, Wen-Zheng
Wang, Xiao-Dan
Liu, Shuai
Zeng, Yan
Zhang, Jin-Hong
Lv, Yang
Niu, Jian-ping
Meng, Xin-ling
Cai, Pan
Li, Yang
Gang, Bao-zhi
You, Yong
Lv, Yan
Ji, Yong
author_sort Wang, Fei
collection PubMed
description BACKGROUND: Constipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two. Most of the studies on constipation in dementia patients have focused on the population with α-synucleinopathies [Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB)]. Few studies have reported the prevalence of constipation in all-cause dementia and mild cognitive impairment (MCI) populations. OBJECTIVE: To assess the prevalence of constipation in patients with all-cause dementia and MCI subtypes and to explore the association between constipation with dementia and MCI subtypes. METHODS: From May 2019 to December 2019, we conducted a population-based cross-sectional survey. A total of 11,743 participants aged 65 or older from nine cities in China were surveyed. Participants underwent a series of clinical examinations and neuropsychological measurements. Constipation, dementia, MCI and MCI subtype were diagnosed according to established criteria through standard diagnostic procedures. RESULTS: The overall age- and sex-adjusted prevalence of constipation in individuals aged 65 years and older was 14.8% (95% CI, 14.6–15.0). The prevalence rates of constipation were19.2% (95% CI, 17.3–21.0), 19.1% (95% CI, 16.8–21.5), 14.4% (95% CI, 12.8–15.9), and 13.8% (95% CI, 13.0–14.6) in the dementia, non-amnestic (na)-MCI, amnestic (a)-MCI and normal cognition populations, respectively. Multivariate logistic regression analysis showed that higher prevalence of constipation was associated with dementia (p = 0.0.032, OR = 1.18, 95% CI: 1.02–1.38) and na-MCI (p = 0.003, OR = 1.30, 95% CI: 1.09–1.54). CONCLUSION: The present study found a high prevalence of constipation in elderly individuals in China, and higher in patients with dementia and na-MCI.
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spelling pubmed-88191402022-02-08 Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study Wang, Fei Fei, Min Hu, Wen-Zheng Wang, Xiao-Dan Liu, Shuai Zeng, Yan Zhang, Jin-Hong Lv, Yang Niu, Jian-ping Meng, Xin-ling Cai, Pan Li, Yang Gang, Bao-zhi You, Yong Lv, Yan Ji, Yong Front Neurosci Neuroscience BACKGROUND: Constipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two. Most of the studies on constipation in dementia patients have focused on the population with α-synucleinopathies [Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB)]. Few studies have reported the prevalence of constipation in all-cause dementia and mild cognitive impairment (MCI) populations. OBJECTIVE: To assess the prevalence of constipation in patients with all-cause dementia and MCI subtypes and to explore the association between constipation with dementia and MCI subtypes. METHODS: From May 2019 to December 2019, we conducted a population-based cross-sectional survey. A total of 11,743 participants aged 65 or older from nine cities in China were surveyed. Participants underwent a series of clinical examinations and neuropsychological measurements. Constipation, dementia, MCI and MCI subtype were diagnosed according to established criteria through standard diagnostic procedures. RESULTS: The overall age- and sex-adjusted prevalence of constipation in individuals aged 65 years and older was 14.8% (95% CI, 14.6–15.0). The prevalence rates of constipation were19.2% (95% CI, 17.3–21.0), 19.1% (95% CI, 16.8–21.5), 14.4% (95% CI, 12.8–15.9), and 13.8% (95% CI, 13.0–14.6) in the dementia, non-amnestic (na)-MCI, amnestic (a)-MCI and normal cognition populations, respectively. Multivariate logistic regression analysis showed that higher prevalence of constipation was associated with dementia (p = 0.0.032, OR = 1.18, 95% CI: 1.02–1.38) and na-MCI (p = 0.003, OR = 1.30, 95% CI: 1.09–1.54). CONCLUSION: The present study found a high prevalence of constipation in elderly individuals in China, and higher in patients with dementia and na-MCI. Frontiers Media S.A. 2022-01-24 /pmc/articles/PMC8819140/ /pubmed/35140587 http://dx.doi.org/10.3389/fnins.2021.821654 Text en Copyright © 2022 Wang, Fei, Hu, Wang, Liu, Zeng, Zhang, Lv, Niu, Meng, Cai, Li, Gang, You, Lv and Ji. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Fei
Fei, Min
Hu, Wen-Zheng
Wang, Xiao-Dan
Liu, Shuai
Zeng, Yan
Zhang, Jin-Hong
Lv, Yang
Niu, Jian-ping
Meng, Xin-ling
Cai, Pan
Li, Yang
Gang, Bao-zhi
You, Yong
Lv, Yan
Ji, Yong
Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
title Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
title_full Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
title_fullStr Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
title_full_unstemmed Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
title_short Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
title_sort prevalence of constipation in elderly and its association with dementia and mild cognitive impairment: a cross-sectional study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819140/
https://www.ncbi.nlm.nih.gov/pubmed/35140587
http://dx.doi.org/10.3389/fnins.2021.821654
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