Cargando…
Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
BACKGROUND: Constipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two. Most of the studies on consti...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819140/ https://www.ncbi.nlm.nih.gov/pubmed/35140587 http://dx.doi.org/10.3389/fnins.2021.821654 |
_version_ | 1784645990925467648 |
---|---|
author | Wang, Fei Fei, Min Hu, Wen-Zheng Wang, Xiao-Dan Liu, Shuai Zeng, Yan Zhang, Jin-Hong Lv, Yang Niu, Jian-ping Meng, Xin-ling Cai, Pan Li, Yang Gang, Bao-zhi You, Yong Lv, Yan Ji, Yong |
author_facet | Wang, Fei Fei, Min Hu, Wen-Zheng Wang, Xiao-Dan Liu, Shuai Zeng, Yan Zhang, Jin-Hong Lv, Yang Niu, Jian-ping Meng, Xin-ling Cai, Pan Li, Yang Gang, Bao-zhi You, Yong Lv, Yan Ji, Yong |
author_sort | Wang, Fei |
collection | PubMed |
description | BACKGROUND: Constipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two. Most of the studies on constipation in dementia patients have focused on the population with α-synucleinopathies [Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB)]. Few studies have reported the prevalence of constipation in all-cause dementia and mild cognitive impairment (MCI) populations. OBJECTIVE: To assess the prevalence of constipation in patients with all-cause dementia and MCI subtypes and to explore the association between constipation with dementia and MCI subtypes. METHODS: From May 2019 to December 2019, we conducted a population-based cross-sectional survey. A total of 11,743 participants aged 65 or older from nine cities in China were surveyed. Participants underwent a series of clinical examinations and neuropsychological measurements. Constipation, dementia, MCI and MCI subtype were diagnosed according to established criteria through standard diagnostic procedures. RESULTS: The overall age- and sex-adjusted prevalence of constipation in individuals aged 65 years and older was 14.8% (95% CI, 14.6–15.0). The prevalence rates of constipation were19.2% (95% CI, 17.3–21.0), 19.1% (95% CI, 16.8–21.5), 14.4% (95% CI, 12.8–15.9), and 13.8% (95% CI, 13.0–14.6) in the dementia, non-amnestic (na)-MCI, amnestic (a)-MCI and normal cognition populations, respectively. Multivariate logistic regression analysis showed that higher prevalence of constipation was associated with dementia (p = 0.0.032, OR = 1.18, 95% CI: 1.02–1.38) and na-MCI (p = 0.003, OR = 1.30, 95% CI: 1.09–1.54). CONCLUSION: The present study found a high prevalence of constipation in elderly individuals in China, and higher in patients with dementia and na-MCI. |
format | Online Article Text |
id | pubmed-8819140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88191402022-02-08 Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study Wang, Fei Fei, Min Hu, Wen-Zheng Wang, Xiao-Dan Liu, Shuai Zeng, Yan Zhang, Jin-Hong Lv, Yang Niu, Jian-ping Meng, Xin-ling Cai, Pan Li, Yang Gang, Bao-zhi You, Yong Lv, Yan Ji, Yong Front Neurosci Neuroscience BACKGROUND: Constipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two. Most of the studies on constipation in dementia patients have focused on the population with α-synucleinopathies [Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB)]. Few studies have reported the prevalence of constipation in all-cause dementia and mild cognitive impairment (MCI) populations. OBJECTIVE: To assess the prevalence of constipation in patients with all-cause dementia and MCI subtypes and to explore the association between constipation with dementia and MCI subtypes. METHODS: From May 2019 to December 2019, we conducted a population-based cross-sectional survey. A total of 11,743 participants aged 65 or older from nine cities in China were surveyed. Participants underwent a series of clinical examinations and neuropsychological measurements. Constipation, dementia, MCI and MCI subtype were diagnosed according to established criteria through standard diagnostic procedures. RESULTS: The overall age- and sex-adjusted prevalence of constipation in individuals aged 65 years and older was 14.8% (95% CI, 14.6–15.0). The prevalence rates of constipation were19.2% (95% CI, 17.3–21.0), 19.1% (95% CI, 16.8–21.5), 14.4% (95% CI, 12.8–15.9), and 13.8% (95% CI, 13.0–14.6) in the dementia, non-amnestic (na)-MCI, amnestic (a)-MCI and normal cognition populations, respectively. Multivariate logistic regression analysis showed that higher prevalence of constipation was associated with dementia (p = 0.0.032, OR = 1.18, 95% CI: 1.02–1.38) and na-MCI (p = 0.003, OR = 1.30, 95% CI: 1.09–1.54). CONCLUSION: The present study found a high prevalence of constipation in elderly individuals in China, and higher in patients with dementia and na-MCI. Frontiers Media S.A. 2022-01-24 /pmc/articles/PMC8819140/ /pubmed/35140587 http://dx.doi.org/10.3389/fnins.2021.821654 Text en Copyright © 2022 Wang, Fei, Hu, Wang, Liu, Zeng, Zhang, Lv, Niu, Meng, Cai, Li, Gang, You, Lv and Ji. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wang, Fei Fei, Min Hu, Wen-Zheng Wang, Xiao-Dan Liu, Shuai Zeng, Yan Zhang, Jin-Hong Lv, Yang Niu, Jian-ping Meng, Xin-ling Cai, Pan Li, Yang Gang, Bao-zhi You, Yong Lv, Yan Ji, Yong Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study |
title | Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study |
title_full | Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study |
title_fullStr | Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study |
title_full_unstemmed | Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study |
title_short | Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study |
title_sort | prevalence of constipation in elderly and its association with dementia and mild cognitive impairment: a cross-sectional study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819140/ https://www.ncbi.nlm.nih.gov/pubmed/35140587 http://dx.doi.org/10.3389/fnins.2021.821654 |
work_keys_str_mv | AT wangfei prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT feimin prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT huwenzheng prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT wangxiaodan prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT liushuai prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT zengyan prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT zhangjinhong prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT lvyang prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT niujianping prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT mengxinling prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT caipan prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT liyang prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT gangbaozhi prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT youyong prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT lvyan prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy AT jiyong prevalenceofconstipationinelderlyanditsassociationwithdementiaandmildcognitiveimpairmentacrosssectionalstudy |